Higher Affinity Heptapeptides Against Influenza Hemagglutinin-Sialic Acid Identification for Treating Flu Virus Disease Ahmed ”e” Al Qaffas.

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Presentation transcript:

Higher Affinity Heptapeptides Against Influenza Hemagglutinin-Sialic Acid Identification for Treating Flu Virus Disease Ahmed ”e” Al Qaffas

Would Peptide therapy provide a better solution? People at risk of any pandemic Vaccine is not enough Current anti-Flu drugs inadequacy Would Peptide therapy provide a better solution?

found them! Mimicking sialic acid function. Easily synthesized. Their binding can be predicted with Dock simulation. They are target specific. Figure1) shows a competitive assay to measure the binding of heptapeptide f1 to HA of H1N1 influenza virus.

Structural based prediction Predicting and validating the binding of these peptides provide a better solution to pandemics outburst of influenza disease. Easy to Test Time efficient Structural based prediction

Human Anti-flu antibodies His-tag substrate Heptapeptide chain Well Step 3 Step 5 Step 1 Washing the well Step 2 Step 4 influenza strain X Goat’s Anti-Human Antibodies

Similar Results Docking visual Prediction of Peptide-HA binding site.