Estimating the monetary impact of the project D.A. Sarigiannis1,2 1 Environmental Engineering Laboratory Department of Chemical Engineering, Aristotle University of Thessaloniki GR-54124, Thessaloniki, Greece 2 Chair of Environmental Health Engineering, Institute of Advanced Study, Pavia 27100, Italy

Steps Estimate previous exposure levels Account for multiple routes (if relevant) Age and gender differentiated Use of a dose-response (CRF, slope factor…….) Estimate relative risk Identify size of affected population Estimate impact Estimate DALYs (see following tables) Estimate reduced exposure after the CROME intervention …………………… Estimate Avoided DALYs Translate avoided DALYs into monetary values Assume 1 DALY = 3 times GDP (WHO suggestion, to be checked)

DALYs Disease type YLLe (y) YLDe (y) DALYe (y) Cancer   Mouth and oropharynx cancer 5.7 0.5 6.2 Oesophagus cancer 17.6 0.4 17.9 Stomach cancer 13 0.6 13.6 Colon and rectum cancer 8 0.8 8.8 Liver cancer 22.1 22.5 Pancreas cancer 15.9 0.3 16.2 Trachea, bronchus and lung cancer 16.5 Melanoma and other skin cancer 6.1 0.2 6.3 Breast cancer 7.2 7.6 Cervix uteri cancer 11.7 12.0 Corpus uteri cancer 3.7 4.0 Ovary cancer 13.3 Prostate cancer 3.3 3.9 Bladder cancer 4.6 5.0 Lymphomas and multiple myeloma 13.9 14.2 Leukemia 28 28.3 Cancer average 11.0 11.5 Neuropsychiatric conditions Bipolar disorder 0.1 0.7 Schizophrenia 1.9 23.4 25.3 Epilepsy Dementia 1.3 5 Parkinson disease 1.8 4.7 6.5 Multiple sclerosis 13.2 19.7 Obsessive-compulsive disorder Panic disorder Neurodevelopmental disorders Cognitive impairment 5.9 Mental retardation 24.5 1.1 Cardiovascular diseases Rheumatic heart disease 19.2 20.5 Ischemic heart disease 8.5 9.2 Cerebrovascular heart disease 11 12.2 Inflammatory heart disease 5.5 Respiratory diseases Chronic obstructive pulmonary disease 3.2 8.2 Asthma Diabetes mellitus 0.9 2.2

DALYs Disease type YLLe (y) YLDe (y) DALYe (y) Digestive diseases   Peptic ulcer 0.6 0.3 1.0 Liver cirrhosis 17 2.6 19.5 Genitourinary diseases Nephritis and nephrosis 11.6 0.8 12.4 Benign prostate hypertrophy 0.04 0.4 Musculoskeletal diseases Rheumatoid arthritis 0.1 1.4 1.5 Osteoarthritis 2.7 Congenital anomalies Abdominal wall defect 45 Anencephaly 80 Anorectal atresia 16 0.2 16.2 Cleft lip 3.6 6.2 Cleft palate 5.8 7.8 13.6 Oesophageal atresia Renal agenesis Down syndrome 36.4 55.9 Congenital heart anomalies 18.5 20.1 38.6 Spina bifida 32 37.9 69.9