The Journal of Allergy and Clinical Immunology: In Practice

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The Journal of Allergy and Clinical Immunology: In Practice A three-level stepwise oral food challenge for egg, milk, and wheat allergy Noriyuki Yanagida, MD, Takanori Minoura, MD, PhD, Setsuko Kitaoka, MD, PhD, Motohiro Ebisawa, MD, PhD The Journal of Allergy and Clinical Immunology: In Practice DOI: 10.1016/j.jaip.2017.06.029 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Patient enrollment. A stepwise oral food challenge (OFC) (STEP 0, STEP 1, STEP 2, and STEP 3; Table E1, available in this article's Online Repository at www.jaci-inpractice.org) was administered. OIT, Oral immunotherapy. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Fitted probability curves demonstrating stepwise oral food challenge (OFC) outcomes with respect to immunoglobulin E levels against (A) egg white, (B) ovomucoid, (C) milk, and (D) wheat. The probability curve was subdivided by the total cumulative dose of 3 different OFCs. sIgE, Specific IgE. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure E1 Differences in specific IgE (sIgE) titers for causative foods. Patients in the 4 groups differed significantly in sIgE levels when exposed to causative foods. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure E2 Fitted probability curves demonstrating stepwise oral food challenge (OFC) outcomes among patients aged 4 years or younger with respect to immunoglobulin E levels against (A) egg white, (B) ovomucoid, (C) milk, and (D) wheat. sIgE, Specific IgE. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure E3 Fitted probability curves demonstrating stepwise oral food challenge (OFC) outcomes among patients older than 4 years with respect to immunoglobulin E levels against (A) egg white, (B) ovomucoid, (C) milk, and (D) wheat. sIgE, Specific IgE. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure E4 Fitted probability curves demonstrating stepwise oral food challenge (OFC) outcomes for the best case with respect to immunoglobulin E levels against (A) egg white, (B) ovomucoid, (C) milk, and (D) wheat. This analysis included patients who received oral immunotherapy or patients who did not undergo STEP 2 or STEP 3 oral food challenges. Patients who did not undergo STEP 2 or STEP 3 were regarded as those who tolerated STEP 3. sIgE, Specific IgE. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions

Figure E5 Fitted probability curves demonstrating stepwise oral food challenge (OFC) outcomes for the worst case with respect to immunoglobulin E levels against (A) egg white, (B) ovomucoid, (C) milk, and (D) wheat. This analysis included patients who received oral immunotherapy or patients who did not undergo STEP 2 or STEP 3 oral food challenges. Patients who did not undergo STEP 2 or STEP 3 were regarded as those who reacted to STEP 2 or STEP 3. sIgE, Specific IgE. The Journal of Allergy and Clinical Immunology: In Practice DOI: (10.1016/j.jaip.2017.06.029) Copyright © 2017 The Authors Terms and Conditions