CARE: CENTER for ANESTHESIA RESEARCH EXCELLENCE Anesthesia Grand Rounds February 4, 2015 Balachundhar Subramaniam, MD MPH Valerie Banner-Goodspeed

Why CARE? Our department has strong interest in research. 2/4/15 Why CARE? Our department has strong interest in research. Without a full study team, it is difficult to conduct research on top of existing responsibilities.

2/4/15 What is CARE? CARE is a one-stop shop for department members who want help conducting clinical research. Our goal is to simplify and streamline research endeavors in the department, and help make you more successful in your research.

Medical Director of Research Education & simulation 2/4/15 CARE Structure Medical Director of Research Clinical Research Administrator Critical Care Pain Cardioth OB/General Education & simulation Research students Statistical Core Physician Panel IRB-SRO

2/4/15 Where does CARE fit in? CARE IRB SRO review CTO (industry funding, contracts) Anesthesia Department members Research administration (grants, student funding)

CARE Timeline We Are Here July-Aug 2014 Develop operating plan 2/4/15 CARE Timeline July-Aug 2014 Develop operating plan Survey department Hire staff Sep 2014 Present plan to department Incorporate suggestions Oct 2014 Center launch Formally begin accepting proposals Jan 2015 Update to department Public relations push June 2015 Interim review of center progress We Are Here

CARE Services Development of core research idea Data analysis 2/4/15 CARE Services Development of core research idea Data analysis Data collection and source documentation Study design Mentorship facilitation Audit readiness Protocol writing Research regulation education, team training IRB communications Manuscript & grant writing Database and Case Report Form building Sample processing & storage Survey design Administration of John Hedley-Whyte Award Patient screening & recruitment strategies

Research Domains Within CARE 2/4/15 Research Domains Within CARE Study Types Interventional trials Physiologic studies Epidemiologic studies Education research Simulation research Quality Improvement research Outcomes research Divisions Represented Critical Care Cardiothoracic Pain Medicine OB General Education/QI

CARE must prioritize projects 2/4/15 How Does CARE Work? You bring the research idea: contact Bala & Valerie Present to the Physician Review Panel Modifications based on feedback and suggestions CARE sends proposal of resources to support you Provide CARE with regular updates on your progress CARE must prioritize projects

What Do You Need To Do? Bring good ideas Be willing to work 2/4/15 What Do You Need To Do? Bring good ideas Be willing to work CARE facilitates, does not replace Notify us about your success: publications, presentations, grants Grants: notify Tanya Santos CV: shared drive (S:\Anesthesia\CV's) CARE is not a free ride

CARE Performance Metrics 2/4/15 CARE Performance Metrics Active protocols – Approximately 37 Patients enrolled relative to targets Completed studies - 0 Publications & Presentations – 11 publications, 4 presentations *NB: all publications, presentations, etc. must acknowledge CARE* Number of users – 12 projects presented to CARE (Oct-Jan) Funding brought in – Support from existing awards. No new awards Path of research assistants/coordinators – most continuing, several advancing to medical school Customer satisfaction surveys – results currently being compiled

CARE Research Committee 2/4/15 CARE Research Committee Faculty hour, 2nd Tuesday. Open to faculty & trainees. Upcoming Topics: Feb: Statistics: power calculations, sample size estimates Mar: Grantsmanship Apr: IRB application process May: Research consenting June: Source documentation Discussion are problem-based using specific examples from the audience – bring your own study questions Topics generated based on August 2014 survey responses

2/4/15 Ways To Get Involved Join the CARE Research Committee: meets once monthly during faculty hour (2nd Tuesday of the month 6:45 am). Contact Bala or Valerie. Attend the proposal review sessions: Meets twice monthly: 1st and 3rd Tuesday at 2 pm. Contact Bala or Valerie. Anesthesia intranet: submission links, archived presentations, templates

2/4/15 CARE Contacts Director of CARE Balachundhar Subramaniam, MD MPH bsubrama@bidmc.harvard.edu Clinical Research Administrator for CARE Valerie Banner-Goodspeed vgoodspe@bidmc.harvard.edu