The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates Anthony Castleberry, MD, MMCI, Michael S. Mulvihill,

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Presentation transcript:

The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates Anthony Castleberry, MD, MMCI, Michael S. Mulvihill, MD, Babatunde A. Yerokun, MD, Brian C. Gulack, MD, Brian Englum, MD, Laurie Snyder, MD, MPH, Mathias Worni, MD, MPH, Asishana Osho, MD, Scott Palmer, MD, R. Duane Davis, MD, MBA, Matthew G. Hartwig, MD The Journal of Heart and Lung Transplantation Volume 36, Issue 7, Pages 780-786 (July 2017) DOI: 10.1016/j.healun.2016.12.015 Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 1 STROBE diagram of candidates analyzed. STROBE, strengthening the reporting of observational studies in epidemiology. WL, waitlist; 6MWD, 6-minute walk distance. The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 2 Kaplan–Meier curves for each 6MWD quartile. The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 3 Six-month waitlist mortality per interval in the 6MWD (each interval contains 200 feet). The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 4 ROC demonstrating optimal cut-off for 6MWD based on 30-day waitlist mortality. AUC = 0.81289. The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 5 ROC demonstrating optimal cut-off for 6MWD based on 6-month waitlist mortality. AUC = 0.67380. The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 6 ROC demonstrating optimal cut-off for 6MWD based on 30-day waitlist mortality for IPF candidates. AUC = 0.71246. The Journal of Heart and Lung Transplantation 2017 36, 780-786DOI: (10.1016/j.healun.2016.12.015) Copyright © 2017 International Society for Heart and Lung Transplantation Terms and Conditions