Volume 14, Issue 11, Pages (November 2013)

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Volume 14, Issue 11, Pages 1514-1521 (November 2013) Pain Relief Is Associated With Improvement in Motor Function in Complex Regional Pain Syndrome Type 1: Secondary Analysis of a Placebo-Controlled Study on the Effects of Ketamine Johanna C.M. Schilder, Marnix J. Sigtermans, Alfred C. Schouten, Hein Putter, Albert Dahan, Lucas P.J.J. Noldus, Johan Marinus, Jacobus J. van Hilten The Journal of Pain Volume 14, Issue 11, Pages 1514-1521 (November 2013) DOI: 10.1016/j.jpain.2013.07.013 Copyright © 2013 American Pain Society Terms and Conditions

Figure 1 Patient flowchart. *Missing recordings at baseline: n = 11 (placebo: n = 6, ketamine: n = 5); week 1: n = 2 (placebo: n = 1, ketamine: n = 1); week 3: n = 4 (placebo: n = 1, ketamine: n = 3); week 6: n = 8 (placebo: n = 4, ketamine: n = 4); week 12: n = 4 (placebo: n = 1, ketamine: n = 3). The Journal of Pain 2013 14, 1514-1521DOI: (10.1016/j.jpain.2013.07.013) Copyright © 2013 American Pain Society Terms and Conditions

Figure 2 Mean NRS pain scores observed in the ketamine (n = 15) and placebo (n = 14) treatment groups obtained by linear mixed model analysis. Bars indicate standard errors. Ketamine has a significantly more favorable effect on pain scores than placebo in weeks 1 and 3 (*P < .001), but not in weeks 6 and 12. The Journal of Pain 2013 14, 1514-1521DOI: (10.1016/j.jpain.2013.07.013) Copyright © 2013 American Pain Society Terms and Conditions

Figure 3 Relation between motor parameters and pain scores at weeks 1, 3, 6, and 12 for both treatment groups. Pearson correlation coefficients are shown on the lower left side of each panel. The Journal of Pain 2013 14, 1514-1521DOI: (10.1016/j.jpain.2013.07.013) Copyright © 2013 American Pain Society Terms and Conditions