The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance Paul M. Young, Hak-kim Chan, Herbert Chiou,

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Presentation transcript:

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance Paul M. Young, Hak-kim Chan, Herbert Chiou, Stephen Edge, Terence H.S. Tee, Daniela Traini Journal of Pharmaceutical Sciences Volume 96, Issue 5, Pages 1331-1341 (May 2007) DOI: 10.1002/jps.20933 Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 1 Influence of mill time on the median particle diameter for freshly milled (●) and recrystallized milled (○) lactose monohydrate samples. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 2 Particle size distributions of (A) freshly milled lactose monohydrate and (B) recrystallized milled samples. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 3 Representative SEM images of freshly milled lactose monohydrate samples after (A) 0 min, (B) 30 min, and (C) 60 min mill times. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 4 Representative SEM images of (A) 60 min freshly milled lactose monohydrate blend and (B) 60 min recrystallized lactose monohydrate blend. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 5 Influence of mill time on the degree of amorphous content in freshly milled lactose monohydrate samples. Milled-recrystallized lactose monohydrate samples were completely crystalline (0.00% amorphous content; not shown). Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 6 Relationship between mill time and fine particle fraction for freshly milled (●) and recrystallized milled (○) lactose monohydrate samples. *R2 relationship for freshly milled samples between 0 and 40 min mill time. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 7 Influence of median particle diameter on fine particle fraction of freshly milled (●, R2 = 0.894) and recrystallized milled (○, R2 = 0.823) lactose monohydrate samples. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 8 Relationship between percentage lactose monohydrate fines content (<10 µm), fine particle fraction for freshly milled (●) and recrystallized milled (○) lactose monohydrate samples. *R2 relationship for freshly milled samples where fines are less than 15%. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

Figure 9 Representative SEM images of (A) freshly milled lactose monohydrate blends containing >15% fines and (B) recrystallized lactose monohydrate blends containing <15% fines. Journal of Pharmaceutical Sciences 2007 96, 1331-1341DOI: (10.1002/jps.20933) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions