Focal nodular hyperplasia Gross appearances of focal nodular hyperplasia. The resemblance to cirrhosis is striking.

Focal nodular hyperplasia Typical star-shaped central scar of radial shape in nodular hyperplasia. The lesion has a brownish cast

Focal nodular hyperplasia Central portion of nodular hyperplasia showing the interphase between the fibrous scar and the hepatocytic nodules.

Large macroregenerative nodule in a cirrhotic liver. It is larger than surrounding cirrhotic nodules but do not display atypical features.

Cavernous hemangioma liver This is a benign hemangioma of the liver just beneath the capsule. Perhaps one person in 50 has such a neoplasm, which is typically just an incidental finding, since most are 1 cm or less. They can sometimes be multiple

Cavernous hemangioma liver variably sized vascular spaces lined by flat endothelial cells and set within a fibrous stroma

Liver cell adenoma a Resected specimen presenting as a pendulous mass arising from the liver. Surgically resected specimen showing a discrete mass underneath the liver capsule

Liver cell adenoma Gross appearance of liver cell adenoma. The tumor, which is well circumscribed, has a large, central area of recent hemorrhage.

Liver cell adenoma Broad cords of liver cells with prominent blood vessels (arrows)

Hepatocellular carcinoma The cancer is unifocal, massive type. A large neoplasm has replaced most of the right hepatic lobe in this noncirrhotic liver. A satellite nodule of cancer is seen in the vicinity of the main mass (arrow)

Hepatocellular carcinoma Note the trabecular pattern of growth, nuclear atypicality, and bile production by tumor cells (Arrows). The broad trabeculae are separated by sinusoides Tubular formations in hepatocellular carcinoma (pseudoglandular HCC). These should not be interpreted as evidence of a cholangiocarcinomatous component. Note the separating sinusoids.

Fibrolamellar carcinoma A, Resected specimen with an outer rim of normal liver. B, Nests and cords of tumor cells separated by dense bundles of collagen.

Multiple hepatic metastases from a primary colon adenocarcinoma.

Metastases to the liver There are numerous variably sized whitish nodules. Some of the larger ones demonstrate central necrosis (umblication) (arrows). The masses are metastases to the liver.

Liver metastases Liver metastases from an adenocarcinoma primary in the colon, one of the most common primary sites for metastatic adenocarcinoma in liver.

Liver metastases Metastatic infiltrating ductal carcinoma from breast is seen on the right, with normal liver parenchyma on the left.