A B C Volume (%) Size (nm) Time (h) 3 x x x 1010

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A B C Volume (%) Size (nm) Time (h) 3 x 1010 2 x 1010 1 x 1010 Tumor Liver Kidney Lung Plasma Volume (%) PdI:0.29 PdI:0.47 Size (nm) 0 0.5 1 2 4 24 24 soluble Time (h)

A A A B B B C C C Protein accumulation (Radiant efficiency/g) 3 x 1010 2 x 1010 1 x 1010 A B C 3 x 1010 2 x 1010 1 x 1010 A B C 3 x 1010 2 x 1010 1 x 1010 A B C Protein accumulation (Radiant efficiency/g) Protein accumulation (Radiant efficiency/g) Protein accumulation (Radiant efficiency/g) Tumor Liver Kidney Lung Plasma Tumor Liver Kidney Lung Plasma Tumor Liver Kidney Lung Plasma Volume (%) Volume (%) Volume (%) PdI:0.29 PdI:0.47 PdI:0.29 PdI:0.47 PdI:0.29 PdI:0.47 Size (nm) Size (nm) Size (nm) Time (h) Time (h) Time (h)