GUT PHYSIOLOGY Absorption 2 Dr. Jack Grider Rm Sanger Hall

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Presentation transcript:

GUT PHYSIOLOGY Absorption 2 Dr. Jack Grider Rm 12-004 Sanger Hall 828-1853 jgrider@vcu.edu 2009

Digestion &Absorption: Lipids Problem: lipids are hydrophobic and enzymes are hydrophillic Solution: Bile (bile salts)

Digestion &Absorption: composition of bile Water & solutes Solutes (4% in hepatic and 10% in gallbladder) 60% bile acids 15% phospholipid 15% electrolyte (Na+, K+, Cl-, HCO3-) 7% cholesterol 2% bilirubin 1% protein

Digestion &Absorption: Lipids

Digestion &Absorption: Lipids

Digestion &Absorption: Lipids ? Potential role as a signaling molecule?

Digestion &Absorption: Lipids Bile Acid = Cholic Acid Conjugated Bile Acid=Taurocholic acid Conjugated Bile Salt=Sodium Taurocholic acid

Digestion &Absorption: Lipids Hydrophillic side Hydrophobic side

Digestion &Absorption: Lipids Micelle increases solubility of FA by >1000 fold

Digestion &Absorption: Lipids Oral cavity: lingual lipase Stomach: gastric lipase; emulsification Intestine: lipase, colipase, bile salts

Digestion &Absorption: Lipids

Digestion &Absorption: Lipids

Digestion &Absorption: Water & Electrolyte

Digestion &Absorption: Water & Electrolyte

Digestion &Absorption: Water & Electrolyte Potassium passive absorption in small intestine secretion in colon if <25mM in lumen absorption in colon if >25 mM in lumen

Digestion &Absorption: Water & Electrolyte Chloride & bicarbonate Bicarbonate secretion in duodenum Absorption of both in jejunum Chloride absorption and bicarbonate secretion in ileum and colon.

Digestion &Absorption: Water & Electrolyte Calcium brush border protein carrier cytosolic calcium binding protein (calbindin) basolateral active transport into capillaries Regulation by PTH and Vitamin D

Digestion &Absorption: Water & Electrolyte Iron dietary is Fe3+ (ferric) but absorbed as soluble Fe2+ (ferrous) form pH-dependent conversion (acidic optimum) Protein complexed absorbed by endocytosis. epithelial cell storage as complex with apoferritin to form ferritin binds to blood protein transferrin mucosal block & desquamation

Digestion &Absorption: Vitamins multiple pathways for water -soluble ones: both passive and specialized mechanisms. fat soluble absorbed with micell.

Digestion &Absorption: Vitamins