Volume 386, Issue 10006, Pages (November 2015)

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Volume 386, Issue 10006, Pages 1853-1860 (November 2015) Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial Lokien X van Nunen, MD, Frederik M Zimmermann, MD, Pim A L Tonino, PhD, Prof Emanuele Barbato, PhD, Prof Andreas Baumbach, MD, Thomas Engstrøm, PhD, Prof Volker Klauss, PhD, Prof Philip A MacCarthy, PhD, Ganesh Manoharan, MD, Prof Keith G Oldroyd, MD, Peter N Ver Lee, MD, Marcel van't Veer, PhD, Prof William F Fearon, MD, Bernard De Bruyne, PhD, Prof Nico H J Pijls, PhD The Lancet Volume 386, Issue 10006, Pages 1853-1860 (November 2015) DOI: 10.1016/S0140-6736(15)00057-4 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile PCI=percutaneous coronary intervention. The Lancet 2015 386, 1853-1860DOI: (10.1016/S0140-6736(15)00057-4) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier curves for survival free from major adverse cardiac events (A), all-cause mortality (B), all-cause mortality or myocardial infarction (C), and revascularisation (D) FFR=fractional flow reserve. PCI=percutaneous coronary intervention. The Lancet 2015 386, 1853-1860DOI: (10.1016/S0140-6736(15)00057-4) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 3 Subgroup analyses of the primary endpoint major cardiac adverse events at 5 years Data are n/N (%), unless otherwise indicated. Relative risks (with 95% CI) of the primary endpoint are shown by subgroup. FFR=fractional flow reserve. PCI=percutaneous coronary intervention. The Lancet 2015 386, 1853-1860DOI: (10.1016/S0140-6736(15)00057-4) Copyright © 2015 Elsevier Ltd Terms and Conditions