From: Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic.

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Date of download: 6/23/2016 Copyright © 2016 American Society of Anesthesiologists. All rights reserved. Transient receptor potential melastatin 2 (TRPM2)
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From: Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats Anesthes. 2009;110(6):1379-1389. doi:10.1097/ALN.0b013e31819fccd5 Figure Legend: Fig. 5. Anti-interleukin (IL)-10 antibody dose-dependently reverses the amitriptyline-induced upregulation of  phospho  -p38 mitogen-activated protein kinase (MAPK) and heme oxygenase (HO)-1 expression in amitriptyline/morphine-coinfused rats. (  A  ) Western blot of  phospho  -p38 MAPK and HO-1 in the spinal cord dorsal horn of the different treatment groups; β-actin was used as the internal standard (n = 4 of each group). (  B  ) Relative band densities for the  phospho  -p38 MAPK and HO-1 after the different treatments; the results are the mean ± SEM. CONT = saline infusion; MO+AMI = morphine plus amitriptyline coinfusion; MO+AMI/Anti-IL-10Ab = morphine plus amitriptyline coinfusion plus anti-IL-10 antibody injection for 5 days. ***  P  < 0.001 compared with saline-infused control group; +++  P  < 0.001 compared with amitriptyline/morphine-coinfused group.  Date of download: 10/7/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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