Animal Biotechnology
Uses of Genetically Engineered Animals Develop new medical treatments Improve food supply Enhance our understanding of animals (Humans are animals)
Animal Models Animal research has been key to nearly every major medical breakthrough of the last century Required in FDA testing Several common species Alternatives to animal models
Cloning
How are transgenic animals made? Retrovirus-mediated transgenesis Pronuclear microinjection Embryonic Stem Cell Method Sperm-mediated transfer Gene guns
Pronuclear Microinjection
Application of Transgenic Animals “Miracle Grow” Chickens Healthier eggs Dairy industry Disease reduction in livestock Reducing human food poisoning
Transgenic Animals as Bioreactors Use animals to produce proteins Use transgenics to introduce the gene of interest Examples BioSteel ATryn gene
Knockout (& Knockin) Animals
Monoclonal Antibodies