A pooled analysis of MRI in the detection of bone marrow infiltration in patients with malignant lymphoma  X.-X. Jiang, Z.-X. Yan, Y.-Y. Song, W.-L. Zhao  Clinical Radiology  Volume 68, Issue 3, Pages e143-e153 (March 2013) DOI: 10.1016/j.crad.2012.11.002 Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 1 Flow chart for reports included in the meta-analysis. Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 2 Results of Deeks' funnel plot of asymmetry test for publication bias. The non-significant slope indicates that no significant bias was found. ESS, effective sample size (p = 0.70). Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 3 Forest plot of pooled sensitivity and specificity of MRI in detecting bone marrow infiltration of malignant lymphoma. Summary sensitivity and specificity of MRI were 0.82 (95% CI: 0.70–0.90) and 0.79 (95% CI: 0.72–0.84), respectively. Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 4 Summary ROC (SROC) curves of MRI in detecting bone marrow infiltration of malignant lymphoma. Numbers in brackets are 95% CIs. AUC, area under ROC curve; SENS, sensitivity; SPEC, specificity. Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 5 Pre-test probabilities (Prob) and likelihood ratios (LR). (a) With a pre-test probability of bone marrow infiltration of 25%, the post-test probability of bone marrow infiltration, given a negative MRI result, was 7%. (b) With a pre-test probability of bone marrow infiltration of 50%, the post-test probability of bone marrow infiltration, given a positive MRI result, was 80%, and the post-test probability of bone marrow infiltration, given a negative MRI result, was 18%. (c) With a pre-test probability of MRI of 75%, the post-test probability of bone marrow infiltration, given a positive MRI result, was 92%; thus, a positive MRI result can be considered sufficient to confirm bone marrow infiltration. Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions

Figure 6 Single factor regression and subgroup analysis for MRI in detecting bone marrow infiltration of malignant lymphoma. Clinical Radiology 2013 68, e143-e153DOI: (10.1016/j.crad.2012.11.002) Copyright © 2012 The Royal College of Radiologists Terms and Conditions