Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar.

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni
The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division J. Peter Etchells, Laxmi S. Mishra, Manoj Kumar, Liam Campbell, Simon.
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
Mark A. Munger, PharmD, Przemyslaw Radwanski, PharmD, PhD, Greg C
Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer  Anekant Jain, MPharm, Sanjay.
Himanshu Gupta, B. Pharm, M. Pharm, Mohammed Aqil, M
Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors 
Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer  Jing Tian, PhD, Yuangzeng.
From solvent-free microspheres to bioactive gradient scaffolds
Nanomedicine: Nanotechnology, Biology and Medicine
Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy  Shengpeng.
Improved stability and immunological potential of tetanus toxoid containing surface engineered bilosomes following oral administration  Sanyog Jain, Ph.D.,
Pharmacogenetics and future drug development and delivery
Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor 
Improving performance of nanoscale ultrasound contrast agents using N,N- diethylacrylamide stabilization  Reshani H. Perera, PhD, Hanping Wu, MD, PhD,
Evaluation of SERS labeling of CD20 on CLL cells using optical microscopy and fluorescence flow cytometry  Christina M. MacLaughlin, BSc, Edward P.K.
Bogong moths Current Biology
Volume 1, Issue 1, Pages (June 2007)
A Path to Insulin Independence: “The End of the Beginning”
Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain 
Epidemiology of Myelodysplastic Syndromes
Zhihua Liu, Michael J. Lenardo  Developmental Cell 
Volume 154, Issue 1, Pages (July 2013)
Copyright © 2012, Elsevier Inc. All rights Reserved.
Repeated Hemoglobin A1C Ordering in the VA Health System
Copyright © 2013 Elsevier Inc. All rights reserved.
Copyright © 2012, Elsevier Inc. All rights Reserved.
Copyright © 2012, Elsevier Inc. All rights Reserved.
Copyright © 2013 Elsevier Inc. All rights reserved.
Copyright © 2013 Elsevier Inc. All rights reserved.
Organization news Archives of Physical Medicine and Rehabilitation
Modeling Functionality with Use Cases
Copyright © 2012, Elsevier Inc. All rights Reserved.
Plasma Lactescence in Acute Pancreatitis
Volume 21, Issue 9, Pages (September 2014)
Copyright © 2012, Elsevier Inc. All rights Reserved.
Copyright © 2013 Elsevier Inc. All rights reserved.
Copyright © 2012, Elsevier Inc. All rights Reserved.
David Hubel and Torsten Wiesel
Volume 21, Issue 9, Pages (September 2014)
Volume 18, Issue 5, Pages R198-R202 (March 2008)
In This Issue Cell Volume 145, Issue 3, (April 2011)
Presentation transcript:

Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar Verma, PhD, Prabhat Ranjan Mishra, PhD, Narendra Kumar Jain, PhD  Nanomedicine: Nanotechnology, Biology and Medicine  Volume 11, Issue 3, Pages 705-713 (April 2015) DOI: 10.1016/j.nano.2014.11.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic representation of synthesis of MdPPI conjugates. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 TEM photograph of MdPPI conjugate. Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 3 Hemolytic toxicity of various AmB formulations. Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 4 Cytotoxicity of different formulations of AmB against J774A.1 cells. Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 5 Qualitative and quantitative uptake of AmB and MdPPIA by J774A.1 cells (P<0.001 for AmB and MdPPIA). Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 6 Antileishmanial activity of AmB formulations Values represent mean±S.D. (n=6). Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.