Volume 15, Issue 3, Pages (March 2014)

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Volume 15, Issue 3, Pages 267-274 (March 2014) Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER) Prof Fabrice André, MD, Thomas Bachelot, MD, Frederic Commo, MSc, Prof Mario Campone, MD, Monica Arnedos, MD, Véronique Dieras, MD, Magali Lacroix-Triki, MD, Ludovic Lacroix, PharmPhD, Pascale Cohen, PhD, David Gentien, MSc, Jose Adélaide, PhD, Florence Dalenc, MD, Anthony Goncalves, MD, Christelle Levy, MD, Prof Jean-Marc Ferrero, MD, Prof Jacques Bonneterre, MD, Claudia Lefeuvre, MD, Marta Jimenez, MSc, Thomas Filleron, PhD, Prof Hervé Bonnefoi, MD The Lancet Oncology Volume 15, Issue 3, Pages 267-274 (March 2014) DOI: 10.1016/S1470-2045(13)70611-9 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile CGH=comparative genomic hybridisation. *Procedure done twice in 29 patients. The Lancet Oncology 2014 15, 267-274DOI: (10.1016/S1470-2045(13)70611-9) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Distribution of targetable genomic alterations among screened patients The Lancet Oncology 2014 15, 267-274DOI: (10.1016/S1470-2045(13)70611-9) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Genomic alteration and matched targeted therapies Efficacy is expressed as the number of responses, defined as objective response or stable disease for >16 weeks. The Lancet Oncology 2014 15, 267-274DOI: (10.1016/S1470-2045(13)70611-9) Copyright © 2014 Elsevier Ltd Terms and Conditions