Figure 1 Alcohol consumption. A

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Figure 1 Alcohol consumption. A Figure 1 Alcohol consumption. A. Distribution of breath alcohol concentration (BAC) across the acute alcohol cohort in g/kg. Results presented for the entire cohort, and stratified by sex and quartiles of age. B. Distribution of chronic alcohol consumption in KORA S4 in g/d. Results presented for the entire cohort, and stratified by sex and quartiles of age. Outliers truncated at 80 g/d. C. Day-by-day variability of mean BAC for each of the 16 days of the Octoberfest. D. Circadian variability of mean BAC across recruitment days at the Octoberfest. From: Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW) Eur Heart J. 2017;38(27):2100-2106. doi:10.1093/eurheartj/ehx156 Eur Heart J | © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Figure 2 Examples and Prevalence of Cardiac Arrhythmias. A–E Figure 2 Examples and Prevalence of Cardiac Arrhythmias. A–E. Representative ECG recordings obtained in our acute alcohol cohort. ECG recordings show sinus rhythm (A), sinus tachycardia (B), premature atrial complex (C), premature ventricular complex (D), atrial fibrillation (E). F–G. Clustered bars represent the prevalence of the primary outcome of any cardiac arrhythmia (F) and sinus tachycardia (G) in our acute alcohol cohort by quartiles of BAC. Within each cluster, bars represent the overall cohort (green), and sex-stratified results for men (blue) and women (red). Clusters compared by χ<sup>2</sup> test for trend. From: Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW) Eur Heart J. 2017;38(27):2100-2106. doi:10.1093/eurheartj/ehx156 Eur Heart J | © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Figure 3 MunichBREW study conclusions Figure 3 MunichBREW study conclusions. The figure summarizes the study procedures and results in the panel shaded in green. These findings influence the generated hypothesis on ‘Holiday Heart Syndrome’ pathophysiology illustrated in the panel shaded in red. Importantly, additional research is warranted to support this hypothesis. From: Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW) Eur Heart J. 2017;38(27):2100-2106. doi:10.1093/eurheartj/ehx156 Eur Heart J | © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com