A Multisite Neurobehavioral Assessment of FASD South Africa Site subcontract (PI Dr Mattson) Colleen Adnams University of Cape Town CIFASD Meeting, Chapel Hill, 8 January 2009

Mapping the Brain, the Face and Neurocognitive function in FASD South Africa Site subcontract (PI Dr Sowell) 2

Focus Recent Progress Planning for 2009 to meet consortium goals

Neurobehavioural Assessment Project 2008 Nov - funding released Dec / Jan – hired neuropsychologist 2009 Jan – commenced translations of WISC-IV, D-KEFS, CANTAB Standardised Afrikaans administration manual Feb / Mar – Neuropsychologist training on neuroassessment battery March – Neuropsychologist training in San Diego Aim for reliability March / April – pilot testing in Afrikaans April – commence data collection, hire second tester

Face and Brain Imaging Project 2009 Jan – hire research assistant Feb – Dr Narr (UCLA) to visit Goals – review protocols Test phantom data Collect pilot data March – pilot in tandem with neurobehavioral study Standardised Afrikaans fMRI test administration April – commence data collection

Some logistics at SA site Large pool of well described FASD and control children (FASER-SA Epi Phase 2, 3 and 4: >200 FASD and controls aged 7 – 18 yrs) Subjects live in Wellington (75km from CT) Neurobehavioral assessments will take place in Wellington Imaging studies will take place at Stellenbosch University CUBBI Centre (50 km from Wellington) All subjects require transport 6

Data Collection Goals Neurobehavioural Project : 100 FASD 100 Controls 40 Low IQ Total 240 Brain Imaging Project: Year 1 and 2: 40 FASD 40 Controls Repeat Year 3 and 4 40 Controls Total 160 7

Data collection Plan 2009 - 2011 - Dec 2009 Dec 2010 Dec 2011 60 90 40 Neurobehavior-al Assessment Project 60 90 Imaging Project 40