General Shape of a Smooth Muscle Cell

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Presentation transcript:

General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - https://commons.wikimedia.org/wiki/File:Smooth_muscle_tissue.jpg#/media/File:Smooth_muscle_tissue.jpg

Smooth Muscle Motor Units? "1029 Smooth Muscle Motor Units" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC BY 3.0 via Commons - https://commons.wikimedia.org/wiki/File:1029_Smooth_Muscle_Motor_Units.jpg#/media/File:1029_Smooth_Muscle_Motor_Units.jpg

Contraction Patterns in Smooth Muscles Phasic (quick, SkMus-like) and tonic contractions

EC Coupling in Smooth Muscle

Thin and Thick Filament Arrangements in Smooth Muscle

Contraction in Smooth Muscle -- Overview "1028 Smooth Muscle Contraction" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC BY 3.0 via Commons - https://commons.wikimedia.org/wiki/File:1028_Smooth_Muscle_Contraction.jpg#/media/File:1028_Smooth_Muscle_Contraction.jpg "Actin myosin filaments" by Boumphreyfr - Own work. Licensed under CC BY-SA 3.0 via Commons - https://commons.wikimedia.org/wiki/File:Actin_myosin_filaments.png#/media/File:Actin_myosin_filaments.png

Caldesmon

Caldesmon In Relaxed Fibers

Regulation of Smooth Muscle Contraction Thick Filament Regulation (on myosin light chain): -- Modulation by MLCK/MLCP -- Other Mechanisms Thin Filament Regulation (?): -- Does caldesmon have a regulatory role? -- Other mechanisms

Calcium and the Control of MLCK Leading to Control of the Myosin Light Chain

Contracted Smooth Muscle

There is Always a Reverse Process: MLCP phosphatase is inhibited by a Ca++ dependent pathway (but in any case, its maximum activity is lower than MLCK)

SM Contraction and Relaxation: Ca++ and the Regulation of Phosphorylation of the Myosin Light Chain

Regulation via the PKC Pathway PKC = protein kinase C PLC = phospholipase C DAG (diacyl glycerol)

Latch Mechanism?