Hormone Replacement Therapy in Postmenopausal Women: Urinary N-Telopeptide of Type I Collagen Monitors Therapeutic Effect and Predicts Response of Bone.

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Hormone Replacement Therapy in Postmenopausal Women: Urinary N-Telopeptide of Type I Collagen Monitors Therapeutic Effect and Predicts Response of Bone Mineral Density Charles H Chesnut, Norman H Bell, MD, Guy S Clark, MD, Barbara L Drinkwater, PhD, Susan C English, MD, C.Conrad Johnston, MD, Morris Notelovitz, MD, PhD, Clifford Rosen, MD, Daniel F Cain, BS, Karen A Flessland, BS, Nancy J.S Mallinak, BS The American Journal of Medicine Volume 102, Issue 1, Pages 29-37 (January 1997) DOI: 10.1016/S0002-9343(96)00387-7

Fig. 1 Percent change from baseline N-telopeptide of type I collagen (NTx) and bone mineral density (BMD) for hormone replacement therapy (HRT) and control (calcium) groups. The American Journal of Medicine 1997 102, 29-37DOI: (10.1016/S0002-9343(96)00387-7)

Fig. 2 Linear regression of percent change N-telopeptide of type I collagen (NTx) to 6 months and percent change bone mineral density (BMD) to 1 year. The American Journal of Medicine 1997 102, 29-37DOI: (10.1016/S0002-9343(96)00387-7)

Fig. 3 Response to hormone replacement therapy (HRT) at the spine by quartiles N-telopeptide of type I collagen (NTx; baseline, percent change to 6 months). ns = not significantly different from baseline BMD; * = significantly different (P <0.05) from baseline; ** = significantly different (P <0.001) from baseline; *** = significantly different (P <0.0001) from baseline; **** = significantly different (P <0.00001) from baseline. The American Journal of Medicine 1997 102, 29-37DOI: (10.1016/S0002-9343(96)00387-7)

Fig. 4 Response to calcium at the spine by quartiles N-telopeptide of type I collagen (NTx; Average on study). ns = Not significantly different from baseline; * = significantly different (P <0.05) from baseline; ** = significantly different (P <0.001) from baseline. BCE = bone collagen equivalents. The American Journal of Medicine 1997 102, 29-37DOI: (10.1016/S0002-9343(96)00387-7)