Type II Collagen Autoimmunity in Rheumatoid Arthritis

Slides:

Advertisements

Similar presentations

Blood lactate level during extracorporeal life support as a surrogate marker for survival Sung Jun Park, MD, Sang-pil Kim, MD, PhD, Joon Bum Kim, MD,

Advertisements

Todd W. Rice, MD, Gordon R. Bernard, MD

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Hypertension-Lipid Connection: Introduction

Impact Of CMV Reactivation On Relapse In Patients With Acute Leukemia Who Received Allogeneic Stem Cell Transplantation In First Remission: Possible GVL.

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

Ex vivo effects of proNGF and NGF on JIA mononuclear cells.

Jelle de Wit, PhD, M. Hussein Al-Mossawi, MD, Michael H

Matrix Metalloproteinase-9 in Monocytic Myeloid-Derived Suppressor Cells Correlate with Early Infections and Clinical Outcomes in Allogeneic Hematopoietic.

Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis Michael D. Howell, Natalija Novak, Thomas Bieber, Saveria Pastore,

The persistence of humoral and cellular immunities more than three decades after smallpox vaccination S.-H. Kim, S.-G. Yeo, K.-H. Park, J.-W. Bang, H.-B.

Increased Expression of CTLA-4 in Malignant T Cells from Patients with Mycosis Fungoides – Cutaneous T-Cell Lymphoma Henry K. Wong, Adam J. Wilson, Heather.

IL-36γ Is Involved in Psoriasis and Allergic Contact Dermatitis

by Daniela Buglio, Noor M

Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors Philippe Gosset,

Diagnostic Performance of a Cytokine and IFN-γ–Induced Chemokine mRNA Assay after Mycobacterium tuberculosis–Specific Antigen Stimulation in Whole Blood.

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Oxidative Stress–Induced Calreticulin Expression and Translocation: New Insights into the Destruction of Melanocytes Yajun Zhang, Ling Liu, Liang Jin,

The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR- Mutant Non–Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors

Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3 Se Jin Park,

Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with β2-adrenergic agonists Elena Goleva, PhD, Annegret.

Figure 2 Anti-LINGO-1 (Li81) does not affect cytokine production

Volume 54, Issue 4, Pages (October 1998)

Rush immunotherapy results in allergen-specific alterations in lymphocyte function and interferon-γ production in CD4+ T cells Gideon Lack, MD, Harold.

Cytokine Effects Induced by the Human Autoallergen α-NAC

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid.

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes Marcel B.M. Teunissen, Jan.

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D George W. Agak, Min Qin, Jennifer Nobe,

Mature and immature NGF forms in patients with JIA and RA

The Effects of Interleukin 10 and Interferon γ Cytokine Gene Polymorphisms on Survival after Autologous Bone Marrow Transplantation for Patients with.

CD161+ T Cells as Predictive Markers for Acute Graft-versus-Host Disease Sung-Eun Lee, Ji-Young Lim, Jae-Ho Yoon, Seung-Hwan Shin, Byung-Sik Cho, Ki-Seong.

Blood lactate level during extracorporeal life support as a surrogate marker for survival Sung Jun Park, MD, Sang-pil Kim, MD, PhD, Joon Bum Kim, MD,

IL-31 Receptor Alpha Expression in Epidermal Keratinocytes Is Modulated by Cell Differentiation and Interferon Gamma Ruth Heise, Mark M. Neis, Yvonne.

Synovial biology and T cells in rheumatoid arthritis

Go on-pump or off-pump in diabetic patients?

(A) Western ... (A) Western blot showing DTX1 knockdown with siRNA in human CD4+ T cells. Actin was used as the loading control. (B) Purified.

Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1) Thomas Scholzen,

Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin George W. Agak, Stephanie.

T Cell Epitope-Specific Defects in the Immune Response to Cat Allergen in Patients with Atopic Dermatitis Raquel Carneiro, Amanda Reefer, Barbara Wilson,

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes Yang Yu, Jackson Champer,

Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro Elizabeth S. Robinson, Paul Alves,

Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells S.J. Kim, M.S.,

Salvage Esophagectomy for Locoregional Failure After Chemoradiotherapy in Patients With Advanced Esophageal Cancer Changhoon Yoo, MD, Ji Hyun Park, MD,

The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells Juha Punnonen, MD, PhD, Hans Yssel, PhD,

Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin

Staphylococcal Toxins Augment Specific IgE Responses by Atopic Patients Exposed to Allergen Michaël F. Hofer, Ronald J. Harbeck, Patrick M. Schlievert,

IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway Hee Jung Kim, Seok Bean Song, Jung Min Choi, Kyung Moon Kim,

Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37 Hyun Jeong Park, Dae Ho Cho, Hee Jung Kim, Jun Young.

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses Andrea Cavani, Francesca Nasorri,

Josée Lamoureux, PhD, Jana Stankova, PhD, Marek Rola-Pleszczynski, MD

IL-12 affects Dermatophagoides farinae–induced IL-4 production by T cells from pediatric patients with mite-sensitive asthma Takeshi Noma, MD, PhD, Izumi.

Pathogenesisof PsA and RA

A.K.I. Kuroki, Masayuki Iyoda, Takanori Shibata, Tetsuzo Sugisaki

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Non– Small-Cell Lung Cancer Seung Jun Lee, MD, Jinwoo Lee, MD, Young.

Figure 3 Cytokine gene expression in PBMC stimulated with PPD or MBP in vitroCytokine messenger RNA transcripts were isolated from peripheral blood mononuclear.

Direct ex vivo analysis of allergen-specific CD4+ T cells

Corticotropin-Releasing Hormone (CRH) Downregulates Interleukin-18 Expression in Human HaCaT Keratinocytes by Activation of p38 Mitogen-Activated Protein.

Dimethylfumarate Induces Immunosuppression via Glutathione Depletion and Subsequent Induction of Heme Oxygenase 1 Joachim C.U. Lehmann, Joanna J. Listopad,

Tuure Kinnunen, MD, Kalle Jutila, BM, William W

Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling Tao Zheng, Min H. Oh, Sun Y. Oh, John T. Schroeder,

Volume 23, Issue 1, Pages (January 2015)

Volume 20, Issue 4, Pages (April 2012)

Vaccines for Lung Cancer

Interleukin-17A Promotes IgE Production in Human B Cells

Interleukin-4 Suppresses the Enhancement of Ceramide Synthesis and Cutaneous Permeability Barrier Functions Induced by Tumor Necrosis Factor-α and interferon-γ.

The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-γ–producing cells Francesca.

Hyun Jeong Park, Hee Jung Kim, Jun Young Lee, Baik Kee Cho, Richard L

Effectiveness of different routes of misoprostol administration before operative hysteroscopy: a randomized, controlled trial Taejong Song, M.D., Mi.

Increased Type 2 Cytokine Expression by Both CD4+ CD45RO+ T Cells and CD8+ CD45RO+ T Cells in Blood Circulation is Associated with High Serum IgE but.

(A) Western ... (A) Western blot showing DTX1 knockdown with siRNA in human CD4+ T cells. Actin was used as the loading control. (B) Purified.

Presentation transcript:

Type II Collagen Autoimmunity in Rheumatoid Arthritis Wan-Uk Kim, MD, PHD, Mi-La Cho, PHD, Young Ok Jung, MD, So-Youn Min, PHD, Sung-Whan Park, MD, PHD, Do-Jun Min, MD, PHD, Jong-Hyun Yoon, MD, PHD, Ho-Youn Kim, MD, PHD The American Journal of the Medical Sciences Volume 327, Issue 4, Pages 202-211 (April 2004) DOI: 10.1097/00000441-200404000-00006 Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 1 Presence of IgG anti-CII antibodies in human rheumatoid arthritis (RA). [Reprinted from Kim WU, Yoo WH, Park W, et al. IgG antibodies to type II collagen reflect inflammatory activity in patients with rheumatoid arthritis. J Rheumatol 2000;27:575–81. Copyright © 2000 Journal Of Rheumatology Publishing Co. Used with permission.] The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 2 High frequency of CII-reactive T cells and early stage of RA. [Reprinted from Kim HY, Kim WU, Cho ML et al. Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255–274) in patients with rheumatoid arthritis. Arthritis Rheum 1999;42:2085–93. Copyright © 1999 American College of Rheumatology. Used with permission.] The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 3 Increased production of Th1 cytokines by CII-stimulated synovial fluid mononuclear cells (SFMC) and peripheral blood mononuclear cells (PBMC) obtained from RA patients. [Reprinted from Park SH, Min DJ, Cho ML, et al. Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis. Arthritis Rheum 2001;44:561–9. Copyright © 2001 American College of Rheumatology. Used with permission.] The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 4 Generation of CII/CII(255-274) specific T cell lines. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 5 Positive selection of CII/CII (255-271) specific T cell clones. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 6 Increasing interferon-γ (IFN-γ) production in accord to positive selection of CII-specific T cell clones in RA peripheral blood mononuclear cells (PBMC) (o). The concentration of IFN-γ according to the clonal expansion of CII (255-274)–reactive T cells in synovial fluid mononuclear cells (■) from RA patients and PBMC from health control subjects (Δ). The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 7 TCR analysis by RT-PCR-SSCP in RA. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 8 TCR CDR3 analysis of CII specific T cells: Common band found on TCRVb14. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 9 Induction of IL-15, IL-18, and TNF-α mRNA from fibroblast-like synoviocytes (FLS) after 24-hour co-culture. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 10 RA synovial fibroblasts induce IL-15 and TNF-α production in a contact-dependent manner. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 11 Chemokine production by interaction of CII-activated T cells with FLS. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions

Figure 12 Dependence of chemokine production on the duration that T cells was stimulated with CII. (A) FLS + T cells stimulated with CII for 5 days. (B) FLS + T cells stimulated with CII for 15 days. The American Journal of the Medical Sciences 2004 327, 202-211DOI: (10.1097/00000441-200404000-00006) Copyright © 2004 Southern Society for Clinical Investigation Terms and Conditions