Delia Danila, PhD, Evan Johnson, MS, Patrick Kee, MD, PhD

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CT imaging of myocardial scars with collagen-targeting gold nanoparticles Delia Danila, PhD, Evan Johnson, MS, Patrick Kee, MD, PhD Nanomedicine: Nanotechnology, Biology and Medicine Volume 9, Issue 7, Pages 1067-1076 (October 2013) DOI: 10.1016/j.nano.2013.03.009 Copyright © 2013 Terms and Conditions

Figure 1 Stabilization of AuNPs in saline environment (UV data). Three different flocculation assays demonstrating the reproducible relationship between the ratio of PEG-SH:AuNPs and size homogeneity of AuNPs. Discrete and uniform preparations of AuNPs with a diameter of 50nm displays a peak absorbance at 530nm. The magnitude of A530 drops precipitously when AuNPs aggregate as seen when PEG-SH:AuNPs decreases below 50. Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions

Figure 2 Specificity of binding of CNA35-AuNPs to Collagen 1. Solid phase Collagen 1 binding assay was performed by incubating pure CNA35 or CAN35-AuNPs with Collagen 1. The amount of peptide bound to Collagen 1 was measured by a colorimetric method and the level of absorbance at 405nm was proportional to the amount of bound peptide. Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions

Figure 3 Long circulating nature of CNA35-AuNPs in vivo. At baseline, pre-existing diet-related contrast was seen in the intestine and urinary bladder. At 30min after AuNPs injection, blood pool contrast remained visible at around 200-250HU. At 360min after injection, blood pool contrast remained visible at 100-130HU. At 25h after injection, no blood pool contrast was observed. Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions

Figure 4 In vivo targeting of collagen I in myocardial scar with CNA35-AuNP. A hyperintense region was detected by CT scanning in the myocardial scar in a mouse 30days after ischemia–reperfusion of the heart (A) which corresponded to the accumulation of AuNPs enhanced by silver staining (black) in the myocardial scar stained with Picrosirius Red (pink) (C). In contrast, there was a lack of corresponding hyperenhancement by CT imaging (B) or AuNPs retention (D) in a control mouse. Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions

Figure 5 The extent of scar formation in different MI mice. Picrosirius Red (pink) staining revealed that the amount of collagen formation in the myocardial scar was variable even though all the animals were subjected to a similar surgical intervention. Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions

Nanomedicine: Nanotechnology, Biology and Medicine 2013 9, 1067-1076DOI: (10.1016/j.nano.2013.03.009) Copyright © 2013 Terms and Conditions