Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor.

Slides:

Advertisements

Similar presentations

Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane- beclomethasone extrafine inhalation aerosol), in asthma Jennifer.

Advertisements

Reducing relative humidity to control the house dust mite Dermatophagoides farinae Larry G. Arlian, PhD, Jacqueline S. Neal, BS, DiAnn L. Vyszenski-Moher,

W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc

What effect does asthma treatment have on airway remodeling

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy Monica B. Arvidsson, MD, Olle.

Diane J. Pincus, MD, Stanley J. Szefler, MD, Lynn M

Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation Makoto Hoshino, MD, Yutaka Nakamura, MD,

Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma Makoto Hoshino, MDa, Yutaka Nakamura, MDa,

Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose inhaled corticosteroid in patients with.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

Rosa Codina, PhD, Richard F. Lockey, MD

The effect of omalizumab on nasal allergic inflammation

Practice Notes from the AAAI

Badrul A. Chowdhury, MD, PhD

Hydroxychloroquine improves airflow and lowers circulating IgE levels in subjects with moderate symptomatic asthma B.Lauren Charous, MD, Elkan F. Halpern,

Pathophysiology of severe asthma

NAEPP Expert Panel Report

Elephantiasis nostras: A case report

The impact of allergic rhinitis on bronchial asthma

Conjunctivitis medicamentosa

Peter M. Wolfgram, MD, David B. Allen, MD

Side effects of inhaled corticosteroids

Inhaled corticosteroids: Impact on asthma morbidity and mortality

IL-11 expression is increased in severe asthma: Association with epithelial cells and eosinophils Eleanor Minshall, PhDa, Jamila Chakir, PhDb, Michel.

Practice Notes from the AAAAI

Qutayba Hamid, MD, PhD Journal of Allergy and Clinical Immunology

Paul M. O’Byrne, MB, FRCPI, FRCP(C)a, Soren Pedersen, MD, PhDb

The Editors' Choice Journal of Allergy and Clinical Immunology

A review of the current guidelines for allergic rhinitis and asthma

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Physician-targeted program on inhaled therapy for childhood asthma

Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge Adriaan.

News & Notes Journal of Allergy and Clinical Immunology

Direct exposure of carpets to sunlight can kill all mites

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma William.

Molecular virology and immunology of HIV infection

Exercise-induced bronchoconstriction in children: Montelukast attenuates the immediate-phase and late-phase responses Raul E. Melo, MD, Dirceu Solé,

Gross pathology and histopathology of asthma

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

News & Notes Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Observations on emerging patterns of asthma in our society

Inhaled corticosteroids and allergy specialty care reduce emergency hospital use for asthma Michael Schatz, MD, MSa, E.Francis Cook, DScb, Randy Nakahiro,

A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein.

Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools Valérie Bougault, PhD, Lionel Loubaki, MSc,

Eosinophilic esophagitis treated with immunotherapy to dust mites

Preparing patients and health professionals for the transition to chlorofluorocarbon-free inhalers: The British perspective Helen Donohoe, MSc (Econ)

Inhaled β2 -agonists and airway responses to allergen

Practice Notes from the AAAI

Corticosteroids in the treatment of pediatric allergic rhinitis

Determinants of systemic manifestations of food allergy

Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: Effect of topical corticosteroids Pota Christodoulopoulos, BSca,

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

Further studies on the chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy Diane J. Pincus, MD, Teresa R. Humeston,

Diane J. Pincus, MD, Stanley J. Szefler, MD, Lynn M

Footnotes1 Journal of Allergy and Clinical Immunology

National trends in asthma visits and asthma pharmacotherapy,

Prescott G. Woodruff, MD, MPH, Ramin Khashayar, MD, Stephen C

Evelyn Farinas, RPh, MGA, Peter Honig, MD

Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

Successful treatment of eosinophilic gastroenteritis with suplatast tosilate Toshihiro Shirai, MD, Dai Hashimoto, MD, Kenichiro Suzuki, MD, Satoru Osawa,

News & Notes Journal of Allergy and Clinical Immunology

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Differences in airway remodeling between subjects with severe and moderate asthma Carmela Pepe, MD, Susan Foley, MD, Joanne Shannon, MD, Catherine Lemiere,

Presentation transcript:

Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma Makoto Hoshino, MD, Miki Takahashi, MD, Yujiro Takai, MD, JaeJoon Sim, MD Journal of Allergy and Clinical Immunology Volume 104, Issue 2, Pages 356-363 (August 1999) DOI: 10.1016/S0091-6749(99)70379-9 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Effects of treatment with BDP or placebo on the percentage expression of MMP-9 and TIMP-1 in the bronchial mucosa. Horizontal bars represent median values (A, epithelium; B, submucosa). Journal of Allergy and Clinical Immunology 1999 104, 356-363DOI: (10.1016/S0091-6749(99)70379-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Expression of MMP-9 (A and B ) and TIMP-1 (C and D ) in bronchial biopsy specimens before (A and C ) and after (B and D ) treatment with BDP. Journal of Allergy and Clinical Immunology 1999 104, 356-363DOI: (10.1016/S0091-6749(99)70379-9) Copyright © 1999 Mosby, Inc. Terms and Conditions