Figure S3 Young Cells Aged Cells *

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Figure S3 Young Cells Aged Cells * SERUM: Young Aged Young Aged Young Young NOTCH INHIB: - - + - - + Young Cells Aged Cells * Figure S3 The enhancement of aged satellite cell proliferation by young serum is dependent on Notch signaling. Bulk myofibers from young or old mice were cultured in media containing either young or old mouse serum, or young serum containing Delta4 (1.5 mg/ml) and Jagged1 (1 mg/ml), soluble ligands which act as inhibitors of Notch signaling1. BrdU was added on day 3 and cell proliferation was determined (see Methods) as the percentage of BrdU+ nuclei (n=3; *p<0.005). 1. Varnum-Finney,B. et al. Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J. Cell Sci. 113, 4313-4318 (2000).