Orientation for "2017 Spring Seminar Course" February 22, 2017 Takashi Angata (IBC, Academia Sinica)

Objectives of the course To help you develop the following skills: Critically evaluate research reports Organize presentation materials Communicate research findings by oral presentation

Principles (1) Student will choose a research article*, and explain its contents to the professors/peers using slides. *Choose from the articles published in the past 3 years in the following areas: Dysregulation of post-translational modifications involved in disease Structural insight into disease process Key advancement in disease diagnosis or therapy

Principles (2) Student will be evaluated by the professors and peers, based on the following criteria: Comprehension of the topic Content organization Time management Manner of presentation (e.g., eye contact/body language/the use of laser pointer) Fluency in English Performance as "moderator" (coordinator only)

Course schedule Overall order: 2nd year students → 1st year students Date Class 3/1, 3/8 (Prep week; No class) 3/15 Seminar 1 3/22 Seminar 2 3/29 Seminar 3 4/5 Seminar 4 4/12 Seminar 5 4/19 (Mid-term exam week; No class) 4/26 (Seminar by Prof. Gervay-Hague) 5/3 Seminar 6 5/10 Seminar 7 5/17 Seminar 8 5/24 Seminar 9 5/31 Seminar 10 6/7 (No class) 6/14 (Reserved) Overall order: 2nd year students → 1st year students Individual order: Please decide after this introduction. (Ask Elve!)

SOP Choose "coach professor" and article ASAP (and get approval from the coach professor!) Invite "coach professor" and "sit-in professor" (> 10 days before presentation) Prepare 2-page summary and 30-min presentation Send the followings (> 7 days before presentation) Coach/Coordinator/Students/Secretary: Article + Summary Sit-in professor: Summary only Remind the professors to attend your presentation (3 days before presentation) Present at the class

In case you need to change the presentation schedule… Please coordinate the schedule change with your coach professor/sit-in professor/peer (e.g., in case a professor is not available for the scheduled presentation).

Penalties for non-attendance (per presentation) Non-attendance without reason: -2 pts Non-attendance with reason but without evidence: -1 pt (exception: 1-day sick leave, staying at home) Non-attendance with reason and evidence: no penalty Late arrival without reason: -1 pt

"Do"s in article selection Choose a primary research article. Choose an article that has NOT been introduced by others or yourself. Choose a paper that is sufficiently challenging and informative for you (so that you can learn something new).

"Do not"s in article selection Do NOT choose review or protocol (alone). Do NOT choose a paper already introduced in a previous seminar. Do NOT choose a paper that is too easy or too difficult for you to understand/explain. Do NOT choose a paper co-authored by the judges (coach/sit-in/coordinator).

How to find an article (example) Use PubMed (www.ncbi.nlm.nih.gov/pubmed/) Use appropriate search terms and formula: Example 1: Alzheimer's disease AND O-GlcNAc Example 2: quantitative proteomics AND biomarker AND breast cancer Example 3: CRISPR AND Doudna J NOT Zhang F Sample keywords: PTM: phosphorylation, ubiquitination, histone acetylation, glycosylation, O-GlcNAc, etc. Structure: cryo-EM, crystallography, etc. (or "structure") Technology: proteomics, CRISPR, etc. Disease: Alzheimer's disease, Dengue virus, etc.

Useful sources of disease-related information Online Mendelian Inheritance in Man (OMIM) http://www.ncbi.nlm.nih.gov/omim Genetics Home Reference https://ghr.nlm.nih.gov/ American Cancer Society "Cancer A-Z" https://www.cancer.org/cancer.html

How to prepare "introductory summary" Use the provided form. Prepare a "structured abstract" yourself. Structured abstract typically consists of the following elements, with headings: Introduction (Background) Objectives Methods Results Conclusion (See www.nlm.nih.gov/bsd/policy/structured_abstracts.html)

How to prepare/deliver presentations (Online resources) https://www.elsevier.com/connect/how-to-give-a-dynamic-scientific-presentation http://www.nature.com/scitable/ebooks/english-communication-for-scientists-14053993/giving-oral-presentations-14239332 http://www.northwestern.edu/climb/resources/oral-communication-skills/designing-PowerPoint-slides.html "Using Powerpoint and structuring a scientific talk" by Prof. Susan McConnell (ppt & YouTube) https://www.youtube.com/watch?v=Hp7Id3Yb9XQ

Questions?