The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special Turku Coronary Risk Factor Intervention Project Study Michael R. Skilton, PhD, Katja Pahkala, PhD, Jorma S.A. Viikari, MD, PhD, Tapani Rönnemaa, MD, PhD, Olli Simell, MD, PhD, Antti Jula, MD, PhD, Harri Niinikoski, MD, PhD, David S. Celermajer, PhD, FRACP, Olli T. Raitakari, MD, PhD The Journal of Pediatrics Volume 166, Issue 5, Pages 1252-1257.e2 (May 2015) DOI: 10.1016/j.jpeds.2015.01.020 Copyright © 2015 Elsevier Inc. Terms and Conditions
Figure 1 A, SBP, B, PP, and C, BMI in children born SGA (×) and children born with normal birth weight (●). Data shown only for 7, 13, and 18 months, and then annually from 2 to 19 years of age. Adjusted for sex, intervention group, maternal and paternal age at birth; blood pressure models further adjusted for height and adiposity. The Journal of Pediatrics 2015 166, 1252-1257.e2DOI: (10.1016/j.jpeds.2015.01.020) Copyright © 2015 Elsevier Inc. Terms and Conditions
Figure 4 Aortic IMT at age 19 years, and tertiles of average dietary ALA intake throughout childhood, in those born SGA (×) and normal birth weight (●). Ptrend = .001 for SGA; Ptrend = .68 for normal birth weight. Data are mean (95% CI), adjusted for sex, randomized group, maternal and paternal age at birth, and aortic diameter at end diastole. The Journal of Pediatrics 2015 166, 1252-1257.e2DOI: (10.1016/j.jpeds.2015.01.020) Copyright © 2015 Elsevier Inc. Terms and Conditions
Figure 2 Cardiometabolic risk factors in people born SGA (×), and with normal birth weight (●). Results are mean (95% CI), or geometric mean (95% CI) for log-transformed variables (insulin and hs-CRP); derived from all measures during childhood and adolescence. HOMA-IR, homeostatic model assessment of insulin resistance. The Journal of Pediatrics 2015 166, 1252-1257.e2DOI: (10.1016/j.jpeds.2015.01.020) Copyright © 2015 Elsevier Inc. Terms and Conditions
Figure 3 Aortic IMT at age 19 years, and average ALA intake throughout childhood, in those born A, SGA (×) and B, normal birth weight (●). Pinteraction = .01. Adjusted for sex, randomized group, maternal and paternal age at birth, and aortic diameter at end diastole. The Journal of Pediatrics 2015 166, 1252-1257.e2DOI: (10.1016/j.jpeds.2015.01.020) Copyright © 2015 Elsevier Inc. Terms and Conditions