BIOELECTRONICS 1 Dr. Eng. Hani Kasban Mahmoud 6 October University Faculty of Applied Medical Sciences Department of Biomedical equipment and systems Lec1: Introduction to Bioelectronics By Dr. Eng. Hani Kasban Mahmoud 2017 BIOELECTRONICS 1

Introduction to Bioelectronics CHAPTER 1 Introduction to Bioelectronics Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Bioelectronics means the integration of biology with electronic elements for building higher-level functional devices. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Measured biomaterials Revision (Biology) Measured biomaterials Cells Cells are the basic building blocks of all living things. Proteins Proteins are one of the building blocks of body tissue, and can also serve as a fuel source. Enzymes Large molecules that speed up the chemical reactions inside cells. type of protein, Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Measured biomaterials Revision (Biology) Measured biomaterials Deoxyribonucleic Acid (DNA)

Introduction to Bioelectronics Measured biomaterials Revision (Biology) Measured biomaterials The neuron (nerve cell) is the fundamental unit of the nervous system. The basic purpose of a neuron is to receive incoming information and, based upon that information, send a signal to other neurons, muscles, or glands. Neurons are designed to rapidly send signals across physiologically long distances. They do this using electrical signals called nerve impulses or action potentials .

Introduction to Bioelectronics Measured biomaterials Revision (Biology) Measured biomaterials Receptor Receptor is a protein-molecule that receives chemical-signals from outside a cell. When such chemical-signals bind to a receptor, they cause some form of cellular/tissue-response Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Revision (Electronics) Electronic-Components Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Revision (Electronics) Measured Quantities Series Parallel Current Voltage VS = V1 + V2 + V3 VS = V1 = V2 = V3 Resistance RS = R1+ R2 + R3 Power PS = P1 + P2 + P3 Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Equivalent circuit for describing the electrostatic interference. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics Bioelectronic system required the existence of electronic coupling and communication between the biomolecules and the electronic supports. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Introduction to Bioelectronics For example, the intercalation of doxorubicin (2) into the double-stranded DNA formed between a primer nucleic acid associated with an electrode. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Bielectronic system Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Bioelectronics Applications Biomedical instrumentation (traditional and innovative) based on acquisition (sensors), amplification (circuits) and processing (systems) of electrical signals with biological origin. Imaging systems for medical diagnostic employ detectors (solid state), integrated circuits (VLSI) and processing systems (ex. DSP) for the acquisition and the processing of large quantities of information Advanced and multi-disciplinary applications of combined electronics and biology/medicine (bio-labs on chip, acquisition/stimulus of cellular electrical signals, electronics prosthesis). Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Bioelectronics Applications Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Biopotential Biopotential is the voltage produced by the tissue of the body, particularly muscle tissue during a contraction. Electrocardiography depends on measurement of changing potentials in contracting heart muscle. Electromyography and electroencephalography function similarly in the diagnosis of neuromuscular and brain disorders, respectively. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Biopotential Electrodes Biopotential electrode is the transducer interface between the body and the readout circuit that converts the ionic current into electronic current, or vice versa. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Biopotential Electrodes Equivalent Circuit CA and RA represents the impedance associated with the electrode–electrolyte interface, and RS is the resistance of the electrolyte solution. The half-cell potential of the interface is represented with a voltage source, Vhc. Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017

Many thanks Dr. Eng. Hani Kasban Questions?????