Volume 16, Issue 8, Pages 979-989 (August 2015) Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial Prof Claus Rödel, MD, Ullrich Graeven, MD, Prof Rainer Fietkau, MD, Prof Werner Hohenberger, MD, Prof Torsten Hothorn, PhD, Prof Dirk Arnold, MD, Prof Ralf-Dieter Hofheinz, MD, Prof Michael Ghadimi, MD, Hendrik A Wolff, MD, Marga Lang-Welzenbach, MSc, Prof Hans-Rudolf Raab, MD, Prof Christian Wittekind, MD, Prof Philipp Ströbel, MD, Prof Ludger Staib, MD, Prof Martin Wilhelm, MD, Prof Gerhard G Grabenbauer, MD, Hans Hoffmanns, MD, Fritz Lindemann, MD, Anke Schlenska-Lange, MD, Prof Gunnar Folprecht, MD, Prof Rolf Sauer, MD, Prof Torsten Liersch, MD The Lancet Oncology Volume 16, Issue 8, Pages 979-989 (August 2015) DOI: 10.1016/S1470-2045(15)00159-X Copyright © 2015 Elsevier Ltd Terms and Conditions
Figure 1 Trial profile Numbers differ from the previous report14 because data have now become available for several patients with missing data for preoperative treatment, surgery, and postoperative treatment at the time of the first report. *Multiple reasons possible. The Lancet Oncology 2015 16, 979-989DOI: (10.1016/S1470-2045(15)00159-X) Copyright © 2015 Elsevier Ltd Terms and Conditions
Figure 2 Disease-free survival (A) and overall survival (B) in the intention-to-treat population The Lancet Oncology 2015 16, 979-989DOI: (10.1016/S1470-2045(15)00159-X) Copyright © 2015 Elsevier Ltd Terms and Conditions
Figure 3 Cumulative incidence of locoregional recurrences (A) and cumulative incidence of distant recurrences (B) in the intention-to-treat population The Lancet Oncology 2015 16, 979-989DOI: (10.1016/S1470-2045(15)00159-X) Copyright © 2015 Elsevier Ltd Terms and Conditions
Figure 4 Disease-free survival in the intention-to-treat population by patient subgroups according to pretreatment and surgical or pathological factors after preoperative chemoradiotherapy The size of the quadrats represents the proportion of patients. HR=hazard ratio. ECOG=Eastern Cooperative Oncology Group. The Lancet Oncology 2015 16, 979-989DOI: (10.1016/S1470-2045(15)00159-X) Copyright © 2015 Elsevier Ltd Terms and Conditions