Christian Burks CBurks@OntarioGenomics.ca www.OntarioGenomics.ca Fish Genomics in Canada Christian Burks CBurks@OntarioGenomics.ca www.OntarioGenomics.ca

Fish Genomics in Canada Ontario Genomics Institute Fish Genomics Fish Barcode Workshop, 7 June ‘05,

From Central Dogma to Discovery Platforms Importance of boundary conditions in solving systems of differential equations. genomics and proteomics discovery platforms, through attempt to be complete and definably accurate, create boundary conditions genes proteins holistic, high-throughput & systematic approaches to building resources genomics proteomics Fish Barcode Workshop, 7 June ‘05,

Ontario Genomics Institute (OGI) Building a globally-competitive life sciences industry in Ontario Fund top tier science & technology Fund best organized projects Facilitate & precipitate commercialization Focus on societal outcomes 50% co-funding requirement (international collaborations count) Fish Barcode Workshop, 7 June ‘05,

OGI R&D Project Portfolio $320M portfolio of 24 projects to date led by Ontario scientists $3M - $30M per program ($10M average) human health, tech development, agriculture, forestry & environment examine associated impact: ethics, environment, economic, legal & social 2 “platform” projects: proteomics (PTCF) and genomics (GRC) Fish Barcode Workshop, 7 June ‘05,

International Programs Structural Genomics Consortium Led by Aled Edwards @ University of Toronto Detailed three-dimensional structure of 350 proteins (starting point for drug discovery) $115M ICI: work being done in and funded by Canada, United Kingdom & Sweden Segmented DNA Duplications Ontario work led by Steve Scherer @ Hospital for Sick Children Duplicated DNA in neurodevelopmental-diseases and evolution $6M work being done in and funded by Canada & Spain (Genoma España) International Regulome Consortium (in planning & development) Led by Michael Rudnicki @ Ottawa Health Research Institute map the mechanisms and networks that control the genes that comprise the genome $$$ to be determined …. ultimately, $50M - $100M; program development funds from MEDT potential ICI: Canada, Australia, France, Germany, Italy, Netherlands, Singapore, UK & USA Fish Barcode Workshop, 7 June ‘05,

Fish Genomics in Canada Ontario Genomics Institute Fish Genomics Fish Barcode Workshop, 7 June ‘05,

Atlantic Salmon Genomics Leads: Willie Davidson (Simon Fraser U.) & Ben Koop (U. Victoria) Collaboration: Bjorn Hoyheim (Norwegian School of Veterinary Science) Sharing BAC libraries, ESTs, QTL markers, etc. Funding: $6M (Genome Canada & others) & $6M (Norway) Focus: Integrate genetic and physical maps Identify genes ( > 16,000)  linked to disease, stress, growth, and development  use variation for identifying conservation units Characterize gene regions relevant to aquaculture  immune system genes  stress and disease  sex determination Fish Barcode Workshop, 7 June ‘05,

Aquaculture Disease Management Lead: Laura Brown (NRC Institute for Marine Biosciences) Consortium:  NRC Institute for Marine Biosciences, Halifax  NRC Institute for Biological Sciences, Ottawa  Dalhousie University, Department of Microbiology  Fisheries and Oceans Canada Funding: $9M (NRC’s Genomics and Health Initiative & others) Focus: genomics, proteomics & metabolomics  to produce vaccines & vaccine delivery systems for Aeromonas salmonicida  to understand the effects of husbandry stressors on vaccine efficacy Fish Barcode Workshop, 7 June ‘05,

Flatfish Genomics Leads: Susan Douglas (NRC IMB, Canada) & Joan Cerda Luque (IRTA, Spain) Consortium: Genome Canada (NRC IMB, Dep’t of Fisheries and Oceans, Scotian Halibut Ltd.) Genoma España (Nine academic & government organizations, Oryzon Genomics) Funding: $5M ($2M from Genome Canada) Focus: Large-scale genomics and proteomics approaches to enhance the commercial culture of Atlantic Halibut and Senegal Sole.  gene sequencing  expression arrays  genetic linkage maps Fish Barcode Workshop, 7 June ‘05,

Zebrafish Functional Genomics Lead: Marc Ekker (CAREG, U. Ottawa) Funding: CIHR, NSERC Focus: environment --  impact of environmental stressors on genome expressivity  identification of novel biomarkers human health --  screens for novel mutations  model Parkinson’s disease, heart arrhythmia & sexual differentiation  reporter transgenic zebrafish for functional assays Fish Barcode Workshop, 7 June ‘05,

Ontario Genomics Institute Christian Burks CBurks@OntarioGenomics.ca www.OntarioGenomics.ca