Suggested IgE ab testing of suspected soy allergic patients

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Presentation transcript:

Suggested IgE ab testing of suspected soy allergic patients Blood testing with ImmunoCAP™ f14 Soya bean Uncertain clinical history Test negative Convincing clinical history Test positive Uncertain clinical history Test with ImmunoCAP™ Rf353 rGly m 4 Test for possible cross-reactivity: e.g. ImmunoCAP™ f13 Peanut, ImmunoCAP™ Ro214 CCD;MUXF3 from Bromelin or ImmunoCAP™ rPhl p 12; profilin (recombinant). Test negative Test positive IgE ab level << f14 IgE ab level ≥ f14 Conclusion Conclusion Conclusion Conclusion Sensitization to soy cannot be demonstrated and symptoms & clinical observations may be caused by factor(s) other than soy. Further investigation needed. Soy related symptoms probably due to IgE anti-bodies to Gly m 4. In birch pollen sensitized patients the IgE antibodies may originate from sensitization to Bet v 1. Sensitization to soy is present and probably underlies symptoms & clinical observations. Positive soy test result might be due to cross-reactivity of antibodies and the clinical relevance has to be further investigated. Positive soy test result might be due to cross-reactivity of antibodies and the clinical relevance has to be further investigated. Positive soy test result might be due to cross-reactivity of antibodies and the clinical relevance has to be further investigated. 060222 (Attachment to Distributor Info No.2, 2006