Association between borderline neonatal thyroid-stimulating hormone concentrations and educational and developmental outcomes: a population-based record-linkage.

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Presentation transcript:

Association between borderline neonatal thyroid-stimulating hormone concentrations and educational and developmental outcomes: a population-based record-linkage study Dr Samantha J Lain, PhD, Jason P Bentley, MBiostat, Veronica Wiley, PhD, Christine L Roberts, DrPH, Michelle Jack, MBBS, Prof Bridget Wilcken, MD, Natasha Nassar, PhD The Lancet Diabetes & Endocrinology Volume 4, Issue 9, Pages 756-765 (September 2016) DOI: 10.1016/S2213-8587(16)30122-X Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Flowchart of study population AEDC=Australian Early Development Census. NAPLAN=National Assessment Program Literacy and Numeracy. The Lancet Diabetes & Endocrinology 2016 4, 756-765DOI: (10.1016/S2213-8587(16)30122-X) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 Proportion of children with scores lower than the national minimum standard for numeracy by neonate thyroid-stimulating hormone percentile The number of infants in the final 0·5% (>99·5%) of the cohort is too small to appear on figure. The mean proportion of infants who had scores lower than the national minimum standard for the 99·5–99·9th and 99·9–99·95th percentiles are indicated on the graph. Blue shading indicates 95% CI. The Lancet Diabetes & Endocrinology 2016 4, 756-765DOI: (10.1016/S2213-8587(16)30122-X) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 3 Adjusted odds ratios for association between thyroid-stimulating hormone concentrations (TSH) and children who scored lower than the national minimum standard for numeracy according to NAPLAN scores (A) and children who had special needs according to AEDC assessments (B) Error bars show 95% CI. The 75th percentile or lower was used as the reference group. All infants with a TSH concentration lower than the 75th percentile had a similar risk of poor developmental or educational outcomes. The Lancet Diabetes & Endocrinology 2016 4, 756-765DOI: (10.1016/S2213-8587(16)30122-X) Copyright © 2016 Elsevier Ltd Terms and Conditions