Changes in salivary cortisol and corticosteroid receptor-α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia

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Changes in salivary cortisol and corticosteroid receptor-α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia Marco Bonifazi, Anna Lisa Suman, Caterina Cambiaggi, Andrea Felici, Giovanni Grasso, Leda Lodi, Marzia Mencarelli, Michela Muscettola, Giancarlo Carli Psychoneuroendocrinology Volume 31, Issue 9, Pages 1076-1086 (October 2006) DOI: 10.1016/j.psyneuen.2006.06.008 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Mean concentrations (±SE) of salivary free cortisol in patients with fibromyalgia at each time of day before and after the 3-week multidisciplinary treatment program. Psychoneuroendocrinology 2006 31, 1076-1086DOI: (10.1016/j.psyneuen.2006.06.008) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 2 Mean (horizontal line) and individual values of the expression of GR-α mRNA in peripheral blood mononuclear cells of fibromyalgia patients before and after the treatment program. The resulting GR-α mRNA abundance data were normalized against β-actin mRNA abundance. Psychoneuroendocrinology 2006 31, 1076-1086DOI: (10.1016/j.psyneuen.2006.06.008) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 3 Mean values (±SD) of pressure pain threshold (kg/cm2) of tender point sites at pre-admission and before and after the 3-week multidisciplinary treatment program. ANOVA: trapezius F=4.83, p=0.016; occiput F=19.10, p<0.001; ant cervical F=7.13, p=0.003; supraspinatus F=14.06, p<0.001; second rib F=12.29, p<0.001; lateral epicondyle F=5.10, p=0.013; gluteal F=1.53, p=0.234; greater trochanter F=1.85, p=0.175; knee F=4.76, p=0.016. Psychoneuroendocrinology 2006 31, 1076-1086DOI: (10.1016/j.psyneuen.2006.06.008) Copyright © 2006 Elsevier Ltd Terms and Conditions