Effects of Myrtus communis extract treatment in bile duct ligated rats

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Presentation transcript:

Effects of Myrtus communis extract treatment in bile duct ligated rats Ali Sen, PhD, Sevil Ozkan, MD, Kafiye Recebova, MSc, Ozge Cevik, PhD, Feriha Ercan, PhD, Elif Kervancıoglu Demirci, MSc, Leyla Bitis, PhD, Goksel Sener, PhD Journal of Surgical Research Volume 205, Issue 2, Pages 359-367 (October 2016) DOI: 10.1016/j.jss.2016.06.094 Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 1 (A) GSH and (B) SOD levels of the liver tissues in the control (C), MC, BDL, and BDL + MC groups. Each group consists of eight animals. *P < 0.05, **P < 0.01 compared with control group, +P < 0.05 compared with BDL group. Journal of Surgical Research 2016 205, 359-367DOI: (10.1016/j.jss.2016.06.094) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 2 (A) MDA levels and (B) MPO activity values of the liver tissues in the control (C), MC, BDL, and BDK + MC groups. Each group consists of eight animals. ***P < 0.001 compared with control group, ++P < 0.01, +++P < 0.001 compared with BDL group. Journal of Surgical Research 2016 205, 359-367DOI: (10.1016/j.jss.2016.06.094) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 3 (A) Luminol and (B) Lucigenin CL values of the liver tissues in the control (C), MC, BDL, and BDL + MC groups. Each group consists of eight animals. ***P < 0.001 compared with control group. +++P < 0.001 compared with BDL group. Journal of Surgical Research 2016 205, 359-367DOI: (10.1016/j.jss.2016.06.094) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 4 (A) TGF-β and (B) hydroxyproline values of the liver tissues in the control (C), MC, BDL, and BDL + MC groups. Each group consists of eight animals. ***P < 0.001 compared with control group. +P < 0.05 compared with BDL group. Journal of Surgical Research 2016 205, 359-367DOI: (10.1016/j.jss.2016.06.094) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 5 Normal liver parenchyma with hepatocytes, sinusoids, and portal tracts were observed in the control (A, B) and MC-treated control (C, D) groups. Disorganization of hepatic cords, increased number of degenerated hepatocytes (arrowhead), fibrosis in the form of delicate bands around the acini and bile duct proliferation within the portal tract (*), and inflammatory cell infiltration (arrow) in parenchyma. (E, F) were seen in BDL group. Mild disorganization of hepatic cords, decrease in degenerated hepatocytes (arrowhead) and inflammatory cell infiltration, moderate fibrosis around the acini, and decreased bile duct proliferation (*) were observed in BDL + MC group (G, H). (A, C, E, G) Hematoxylin and eosin staining; (B, D, F, H) Gomori's one-step trichrome staining. Original magnifications × 400. (Color version of figure is available online.) Journal of Surgical Research 2016 205, 359-367DOI: (10.1016/j.jss.2016.06.094) Copyright © 2016 Elsevier Inc. Terms and Conditions