Serum Creatinine Presented By Assist.Lecturer Aseel Ghassan Daoud

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Serum Creatinine Presented By Assist.Lecturer Aseel Ghassan Daoud M.Sc. In pharmacy/ Clinical laboratory sciences

What is creatinine and creatinine clearance test? This test measures the level of the waste product creatinine in blood and urine This test provides more sensitive measure of renal damage than blood urea? What is creatinine? It is a non protein end product of creatine metabolism Its amount in serum is proportional to muscle mass

It is easily excreted by kidneys with minimum or no tubular reabsorption It is directly related to GFR Its level remains normally constant Blood creatinine level: It shows how well the kidneys are working It is higher in men than in women

Creatinine clearance test: It measures how well creatinine is removed from the body by kidneys It gives better information than blood creatinine test on how well the kidneys are working It is done on both a blood or urine sample

Reference values: Serum Men: 0.7-1.2 mg/dl Women: 0.5-0.9 mg/dl Clearance test Men: 97-137 ml/min Women: 88-128 ml/min

Pathological: Increase: Increased rate of formation:

Diminished renal excretion of creatinine:

Decrease: Muscle disease such as muscle dystrophy

What are medicines that increase blood creatinine? Anti hypertensives: ACE inhibitors ex: captopril NSAIDs: ibuprofen, naproxen Diuretics: furosemide Antibiotics: aminoglycosides (gentamicin) and cephalosporins (cefoxitin)