Precision Medicine, Community Engagement, and Native Health Monday, November 14, 2016

Session Objectives Understand Precision Medicine and why a diverse cohort is crucial for success Describe the nuanced issues in Precision Medicine and genetic research as applied to Native populations Develop strategies to engage Native populations in discussions about and participation in Precision Medicine

Session Structure Videos, Reflection, and Rapid Report-Out Introduction and Session Overview Contributors to Health Feelings about Precision Medicine Panel Response Group Table Work and Discussion Sharing of Key Ideas

Definition and Goal An approach to disease treatment and prevention intended to maximize effectiveness by taking into account individual variability in genes, environment, and lifestyle. Seeks to redefine our understanding of disease onset and progression, treatment response, and health outcomes through the more precise measurement of potential contributors.

Assumptions A precise delineation of the molecular, environmental, behavioral, and other factors that contribute to health and disease will lead to more accurate diagnoses, more rational disease prevention strategies, better treatment selection, and the development of novel therapies. Coincident with advancing the science of medicine is a changing culture of medical practice and medical research that engages individuals as partners – not just as patients or research subjects.

Examples Targeted treatments for cancer and cystic fibrosis that are effective in patients who share an underlying causal genotype. Information to help ensure that each patient is given the right drug at the right dose the first time. Individual genome sequencing to successfully diagnose conditions in patients with previously undiagnosed genetic diseases.

Contributors to Health Video

Precision Medicine Video

Panelists & Facilitator Ka`imi Sinclair Malia Villegas Ph.D., M.P.H., Western Cherokee Ed.D., Alutiiq/Sugpiaq Assistant Professor, College of Nursing, Director of the Policy Research Center, Washington State University National Congress of American Indians McGarry Houghton Abigail Echo-Hawk M.D., Choctaw M.P.A., Pawnee Associate Professor Pulmonary and Critical Care, University of Washington Director of the Urban Indian Health Institute, Seattle Indian Health Board Denise Dillard Ph.D., Inupiaq Eskimo Research Director, Southcentral Foundation

Table Work

Report Out

aamc.org/healthequity Thank you aamc.org/healthequity healthequityresearch@aamc.org