High calorie diet triggers hypothalamic angiopathy

Slides:

Advertisements

Similar presentations

Lotte B. Bertelsen, Mette Hagensen, Morten Busk, Rui Zhang, Anne S

Advertisements

Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin.

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress Hanke L. Matlung, Annette E.

Trans fat intake lowers total cholesterol and high-density lipoprotein cholesterol levels without changing insulin sensitivity index in Wistar rats Zhiliang.

Heparanase procoagulant activity as a predictor of wound necrosis following diabetic foot amputation Eli Peled, Eyal Melamed, Tali Banker Portal, Elena.

D. A. Walsh, F. R. C. P. , Ph. D. , C. S. Bonnet, B. Sc. , E. L

From: Cfh Genotype Interacts With Dietary Glycemic Index to Modulate Age-Related Macular Degeneration-Like Features in Mice Invest. Ophthalmol. Vis. Sci..

Leptin action in the brain: How (and when) it makes fat burn

Volume 10, Issue 4, Pages (October 2009)

Tumor-Induced Sentinel Lymph Node Lymphangiogenesis and Increased Lymph Flow Precede Melanoma Metastasis Maria I. Harrell, Brian M. Iritani, Alanna Ruddell

Volume 9, Issue 1, Pages (July 2017)

Hubert Kolb, Matthias von Herrath Cell Metabolism

Volume 138, Issue 2, Pages (February 2010)

Nuclear Factor of Activated T Cells 5 Deficiency Increases the Severity of Neuronal Cell Death in Ischemic Injury Neurosignals 2012;20:237–251 - DOI: /

Volume 43, Issue 6, Pages (December 2015)

IFT88 influences chondrocyte actin organization and biomechanics

Supplementary Figure 2 Secondary transplanted brain tumors from PASC1 express human GH. Immuno-fluorescence staining of brain sections from mice implanted.

Epicardial Spindle Orientation Controls Cell Entry into the Myocardium

Volume 23, Issue 2, Pages (February 2016)

Michael A. Rosenbaum, MD, Pinaki Chaudhuri, PhD, Linda M. Graham, MD

Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury.

CREB Regulates Memory Allocation in the Insular Cortex

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions M. Deng, R.D.

Radiation resistance and stem-like cells in brain tumors

Volume 24, Issue 9, Pages (September 2016)

Volume 18, Issue 10, Pages (October 2010)

A novel vascularized patch enhances cell survival and modifies ventricular remodeling in a rat myocardial infarction model Qi Zhou, MD, PhD, Jian-Ye.

Volume 134, Issue 2, Pages (July 2008)

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

Volume 25, Issue 6, Pages (June 2017)

Volume 15, Issue 2, Pages (February 2012)

Rejuvenation of Regeneration in the Aging Central Nervous System

Volume 138, Issue 2, Pages (February 2010)

Volume 9, Issue 6, Pages (December 2014)

D. A. Walsh, F. R. C. P. , Ph. D. , C. S. Bonnet, B. Sc. , E. L

Volume 34, Issue 5, Pages (May 2011)

Kieran M. Short, Mark J. Hodson, Ian M. Smyth Kidney International

Volume 54, Issue 2, Pages (April 2007)

Volume 19, Issue 2, Pages (February 2014)

Volume 16, Issue 4, Pages (February 2006)

Molecular Therapy - Methods & Clinical Development

Critical Role for Hypothalamic mTOR Activity in Energy Balance

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma Muhannad Hassan, MD, Taisuke Jo, MD, PhD, Paul-André Risse, PhD,

Volume 23, Issue 3, Pages (March 2016)

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes Z. Wang, J. Irianto,

Volume 8, Issue 4, Pages (October 2008)

Volume 12, Issue 6, Pages (December 2005)

Volume 15, Issue 5, Pages (May 2012)

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity Pei-Ting Chao,

Epicardial Spindle Orientation Controls Cell Entry into the Myocardium

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

A New Role for Glia in Leptin Action and Energy Balance

Volume 23, Issue 8, Pages (April 2013)

Volume 9, Issue 6, Pages (June 2009)

Volume 5, Issue 1, Pages (January 2007)

Volume 11, Issue 4, Pages (October 2012)

Volume 121, Issue 4, Pages (October 2001)

Volume 21, Issue 4, Pages (April 2013)

Deep vein thrombosis resolution is impaired in diet-induced type 2 diabetic mice Fatiha Bouzeghrane, PhD, Xiaochun Zhang, MD, BSc, Guylaine Gevry, BSc,

Volume 17, Issue 2, Pages (February 2013)

Volume 5, Issue 6, Pages (June 2007)

The Lymphocytic Choriomeningitis Virus Envelope Glycoprotein Targets Lentiviral Gene Transfer Vector to Neural Progenitors in the Murine Brain Colleen.

Volume 80, Issue 7, Pages (October 2011)

Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage C. Zhou, H. Zheng, J.A. Buckwalter,

Volume 7, Issue 2, Pages (February 2008)

Radiation resistance and stem-like cells in brain tumors

Volume 5, Issue 1, Pages (January 2007)

Molecular Therapy - Methods & Clinical Development

PEGPH20 depletes HA and decompresses intratumoral vessels.

Volume 4, Issue 4, Pages (October 2006)

Presentation transcript:

High calorie diet triggers hypothalamic angiopathy Chun-Xia Yi, Martin Gericke, Martin Krüger, Anneke Alkemade, Dhiraj G. Kabra, Sophie Hanske, Jessica Filosa, Paul Pfluger, Nathan Bingham, Stephen C. Woods, James Herman, Andries Kalsbeek, Marcus Baumann, Richard Lang, Javier E. Stern, Ingo Bechmann, Matthias H. Tschöp Molecular Metabolism Volume 1, Issue 1, Pages 95-100 (December 2012) DOI: 10.1016/j.molmet.2012.08.004 Copyright © 2012 Elsevier GmbH Terms and Conditions

Fig. 1 Total vasculature in the ARC was labeled by FITC-albumin in mice fed 18 weeks of either standard chow (SC) diet (A) or high fat high sugar (HFHS) diet (B). The labeled images are skeletonized and shown in C and D. Quantification of the labeled vasculature reveals significantly increased total vessel length (E) and density (F) in the 18 week HFHS DIO mice compared to SC age matched controls. For comparison, total vasculature in the ARC was also labeled by FITC-albumin in mice fed 32 weeks SC diet (G) or HFHS diet (H). Although not quantified, the labeled images are skeletonized and shown in I and J. Molecular Metabolism 2012 1, 95-100DOI: (10.1016/j.molmet.2012.08.004) Copyright © 2012 Elsevier GmbH Terms and Conditions

Fig. 2 After 18 weeks of HFHS diet, mice exhibit more αSMA-ir blood vessels (Green fluorescence, arrows in B) within the ARC than mice fed a SC diet (arrows in A); the ARC is visualized by DAPI staining (blue fluorescence). Ultrastructural analysis of the blood brain barrier after 18 weeks on HFHS diet reveals signs of endothelial degeneration (asterisk in E, F; difference did not reach significance), while tight junctions (arrows in D&E) and basement membranes (arrow heads in D&E) are intact in comparison to SC diet-fed controls. III: third cerebral ventricle. Scale bar: 120μm in A & B, 1.5um in D&E. Molecular Metabolism 2012 1, 95-100DOI: (10.1016/j.molmet.2012.08.004) Copyright © 2012 Elsevier GmbH Terms and Conditions

Fig. 3 Representative pictures of αSMA immunoreactivity in a patient with type 2 diabetes (B) and a matched control (A). A significant increase of αSMA immunoreactive vessel number was observed in diabetic patients hypothalamic infundibular nuclei (IFN), line indicates median value (C). Scale bar: 300μm. Molecular Metabolism 2012 1, 95-100DOI: (10.1016/j.molmet.2012.08.004) Copyright © 2012 Elsevier GmbH Terms and Conditions