Please, complete evaluations. Important to assess faculty performance pedro.fernandez@neurology.ufl.edu Watch video and PPT @: http://neurology.ufl.edu/divisions-2/neuroscience/ gms-6096-introduction-to-nih-grant-writing-for-biomedical-sciences/ Please, complete evaluations. Important to assess faculty performance

Pre-submission review Pedro Fernandez-Funez, PhD Assistant Professor Department of Neurology

By now, you should… Understand the complexity of the NIH grant proposal Identify all the components Work on a timeline to complete the proposal on time

Review: Key documents Documents to upload and submit: Minimum of 12 Scientific proposal: ✔Abstract ✔Narrative ✔Specific Aims ✔Research Strategy ✔References Information: ✔Cover letter ✔PI Biosketch ✔Resource sharing ✔Facilities, Environment ✔Equipment Budget: ✔Modular/detailed budget ✔Budget justification

Preview: Additional documents Extra documents: Key Personnel Biosketch Support letter(s) Consortium Multiple PI Proprietary info Regulatory documents (depending on proposed research): Human subjects IRB permit Vertebrate animals IACUC permit Documents to upload and submit: 15-20

Timeline for submission Announce intent to submit 3-4 months Aims, Sign+Innov for Dept. presentation 2.5 months Complete Research Strategy for COM 1 month R01 deadline Received by NIH Aims, Sign+Innov for COM review 2 months Final Submission 10-15 days Title, Biosk, budget COI, humans? Animals? 3 months -Upload to NIH form -Upload on PeopleSoft -Approvals: PI(s), Chair(s), Dean -COM-RAC review -DSR-UF review and submit Budget justific, Animals, humans, facilities 1.5 months Jun 5 Feb Mar 5 Mar 19 Apr 5 May 5 May 22

The Budget trap ! You don’t have to submit a detailed budget to the NIH, if below 250K/year BUT, you HAVE to your college !

Completing the science Project Summary/Abstract- 30 lines or less You will need to send an introduction to application only if this is a resubmission. Specific Aims- 1 page !!! Research Strategy – Page limits by mechanism or guidelines (12 p. R01, 6 p. R21, R03) Significance and Innovation: 1 page, part of Research Strategy References Cited-Full citations, no page limits

Summary / Abstract Could be considered the most important part of your application since every reviewer in the panel will likely read it 30 lines or less ! Do not include proprietary information If awarded, it will appear on RePORTER

Summary / Abstract Stand alone document: most reviewers will not read the specific aims or the proposal Should be written last to make sure it clearly reflects the content of your proposal Open by describing gap in knowledge followed by key sentences in the Specific Aims Copy the Specific Aims and primary methods Finish with statements of Significance and Innovation

Project Narrative No more than 2 or 3 sentences Layman language Meant to describe the relevance to public health and how it relates to the NIH mission Public Health Relevance/Narrative: Carolina Wahlby, 2010 Large-scale screening experiments that test the effects of thousands of chemicals or genetic perturbants by microscopy and image analysis can discover new treatments and help biomedical scientists understand disease mechanisms. Microscopy screens of cultured cells are routine, but researchers wish to study complex processes like metabolism and infection in a whole animal like the tiny worm Caenorhabditis elegans, for which existing image analysis methods are insufficient. The goal of this research is to develop open-source software to automatically identify and measure C. elegans in microscopy images, thereby making it possible for researchers worldwide to screen a wide variety of complex biological processes related to human disease.

Cayuse 424 New software that allows PI to prepare grant application on their own http://research.ufl.edu/research/proposal/cayuse/cayuse-proposal.html#search

Cayuse 424

Cayuse 424

MyinvestiGator

My Investigator

Remember ! Be responsive to requests from your grants people. After all, it is YOUR grant Your grants person does not submit directly to NIH. Many internal steps to get it through the system

Congratulations ! You completed the course !