Milan, 28th February-1st March 2016 HOME/2014/JDRU/AG/DRUG/7086 Identification & Assessment of NPS: An European Network PARTNER: Faculty of Pharmacy, University of Lisbon Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Faculty of Pharmacy, University of Lisbon One of the 18 schools and institutes from UL (since 2013), the largest public academic higher education institution in Portugal; Raking first among the Schools of Pharmacy in Portugal; Is a highly-regarded research-oriented institution in Pharmaceutical Sciences; Is the host institution of iMed.ULisboa, a multidisciplinary R&D Unit in Life and Health Sciences. We have recently Lost Carlos Barbas. Thank Carlos for his contributions and inspiration to iMed.ULisboa. Milan, 28th February-1st March 2016

1212 Integrated Master In Pharmaceutical Sciences Teaching & Research Pharmaceutical Industry Hospital Pharmacy Clinical Analysis Chemical, Biological Hydrological, Bromatological and Toxicological Analysis Pharmaceutical Distribution Community Pharmacy Regulation of Medicinal Products  We have recently Lost Carlos Barbas. Thank Carlos for his contributions and inspiration to iMed.ULisboa. Integrated Masters Students 1212 Milan, 28th February-1st March 2016

170 Master Programmes Masters Students Clinical Analysis Regulation and Assessment of Medicinal Products Pharmaceutical Intervention and Therapeutical Management Pharmaco-therapy and Pharmaco-epidemiology Pharmaceutical Engeneering (in cooperation with Técnico-ULisboa) Herbal Medicines Bio-pharmaceutical Sciences Quality Control and Food Toxicology Clinical Analysis Pharmaceutical and Medicinal Chemistry We have recently Lost Carlos Barbas. Thank Carlos for his contributions and inspiration to iMed.ULisboa. Masters Students 170 Milan, 28th February-1st March 2016

121 PhD Programme: in Medicines and Pharmaceutical Innovation (i3DU) iMed.ULisboa Members  Total 277 Integrated Members 94 PhD Students 121 Collaborators 62 Technicians & Administrative Staff 8 Other Trainees 61 94 Integrated Members We have recently Lost Carlos Barbas. Thank Carlos for his contributions and inspiration to iMed.ULisboa. PhD Students 121 121 PhD Students Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Resources & Services Integrating the National Roadmap of Research Infrastructures MS; NMR; Translational research (Health Cluster Portugal) Partnering within ESFRI Instruct; EU OpenScreen; EATRIS Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 PROJECT: HOME/2014/JDRU/AG/DRUG/7086 FFUL and EMCES Teams Milan, 28th February-1st March 2016

Team FFUL (Leader of WS2) Name: Dora Brites, Group Leader (Neuron-Glia Biology in Health and Disease) Ana Sofia Falcão, PhD Ana Rita Vaz, PhD Activities: Neuroinflammation and neurotoxic mechanisms in neurodevelopmental diseases, neurodegenerative disorders and ageing, including signaling cascades and target discovery Capabilities: Cell Function/Dysfunction, Cell Biology and Histopathology in vitro cultures (primary cultures and co-cultures in 2D and 3D systems in-vivo models of Alzheimer´s disease and Amyotrophic lateral sclerosis ex-vivo models (organotypic cultures) Neuron-glia communication, exosome dissemination and microRNAs iPSCs and neural derived cells Past experience: Senior researcher at FFULisboa Professor of Histology and Embriology and of Physiopathology of Neuroinflammation Member of the Directive Board of the Doctoral Program in Integrative Neuroscience, Faculty of Medicine, ULisboa Member of the Coordinator Council and of the Executive Director of Mind-Brain College, ULisboa Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Team FFUL (WS1 and WS3) Name: Rui Moreira, Group Leader on Medicinal Chemistry, Coordinator of Pharmaceutical and Therapeutical Chemistry Department) Activities: Organic synthesis, Medicinal chemistry, metabolism studies Capabilities: Laboratories for chemical synthesis, photoreactions, metabolism studies and structural elucidation Past experience: Medicinal Chemistry, with a recent entry in the field of drugs of abuse Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Team FFUL (WS1 and WS3) Name: Maria Bronze, Coordinator of Toxicological and Bromatological Department Activities: Analytical Chemistry: implementation and validation of methods Capabilities: Sample preparation methodologies: SPE, SPME... Separative methodologies : gas and liquid chromatography equipment with mass spectrometry Past experience: Analysis of compounds in different matrices (food, food wastes, water, biological fluids) Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Team FFUL (WS1, 2, 3) Name: Cristina Sampayo Activities: Pharmacology, safety and health effects of bioactive compounds in laboratory and target animals, including behaviour and cognitive studies, pharmacodynamics and non-clinical PK NC drug development as Expert member for evaluation of veterinary medicines (GAMV) and Expert at the European Medicines Agency (EMA), including ERA of medicinal products Capabilities: In vitro and ex-vivo models for drug transport studies, d.r.c studies and genotoxicity studies. In vivo motor, behavioural & cognitive studies (ataxia, rota rod, SFT, W-M, T-M, Marble test, Open field, Novel Object Recognition, Conditioned Place Preference tests in rodents) In vivo models of skin, inflammation, metabolic and bone disorders (rodents) FELASA Certificate Cat. C – Directing Animal Experiences (2010) DIA certificate on Non-Clinical Safety Sciences and their Regulatory Aspects (2009) EMA Assessors Training in ERA of Human Medicinal Products (2008) Past experience: 2007-…….. - Pharmacology Teaching & Pharmacotoxicology Teaching (Ms Pharmaceut. Sc., UL & UAL) 2003-2012 - Psychopharmacology Teaching (Ms Psychology, UL & INUAF) 2008-2012 - Environmental Risk Assessment of Human Medicines Teaching (Ms R. Affairs M&HP UL) 2004-2007 - Specialist on the evaluation of human medicines authorized by centralized (EMA) and national procedures at Portuguese Medicines Agency, INFARMED, I.P. Milan, 28th February-1st March 2016

Milan, 28th February-1st March 2016 Team FFUL (WS1 and WS3) Name: Nuno Silva and Paulo Paixão Activities: Modelling and Simulation on Pharmacokinetics and biopharmaceutics; Phase I clinical trials Capabilities: M&S, Software for QSAR and PBPK Past experience: medicinal products pharmacokinetics and clinical trials Milan, 28th February-1st March 2016