Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease  Yasuhiro Nakata, Noriko Sato, Kiyotaka Nemoto, Osamu Abe, Shoko Shikakura, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Masutani, Kuni Ohtomo, A. James Barkovich, Shigeki Aoki  Magnetic Resonance Imaging  Volume 27, Issue 3, Pages 347-354 (April 2009) DOI: 10.1016/j.mri.2008.07.013 Copyright © 2009 Elsevier Inc. Terms and Conditions

Fig. 1 DTT and voxelization along the posterior cingulum. (A) A reconstructed sagittal section of the color-coded map was used to determine reconstructed coronal sections at the level of the splenium of the corpus callosum (light blue line) and the center of the corpus callosum (purple line). (B) The relatively large seed ROI, including the entirety of the cingulum (the white matter within the cingulate gyrus, light blue area), was placed manually on a reconstructed coronal section of the color maps at the level of the splenium of the corpus callosum in the sagittal plane. (C) The relatively large target ROI, including the entire cingulum (purple area), was placed manually on a reconstructed coronal section of the color maps at the level of the center of the corpus callosum in the sagittal plane. (D and E) A three-dimensional display from the posterior upper left with background of sagittal, coronal and axial planes of the color-coded maps. (D) DTT of the posterior cingulate fiber tracts was then generated from the seed ROI (light blue line) in the posterior part of the cingulum to the target ROI (purple line) in the middle part of the cingulum. (E) Voxelization along the posterior cingulate fiber tracts between seed ROI and target ROI was performed (yellow voxels), and MD and FA values in co-registered voxels were calculated. Magnetic Resonance Imaging 2009 27, 347-354DOI: (10.1016/j.mri.2008.07.013) Copyright © 2009 Elsevier Inc. Terms and Conditions

Fig. 2 Correlations among MD/FA values in the posterior cingulate fiber tract (PCFT), hippocampal volume and MMSE scores in patients with AD were evaluated by bivariate correlation analysis (Pearson's r). A correlation existed between MMSE score and MD (*). Magnetic Resonance Imaging 2009 27, 347-354DOI: (10.1016/j.mri.2008.07.013) Copyright © 2009 Elsevier Inc. Terms and Conditions

Fig. 3 Scatterplot showing the correlation between MD values in the posterior cingulate fiber tract (PCFT) and MMSE score in patients with AD. The line was generated by simple linear regression. Magnetic Resonance Imaging 2009 27, 347-354DOI: (10.1016/j.mri.2008.07.013) Copyright © 2009 Elsevier Inc. Terms and Conditions