Volume 14, Issue 10, Pages (October 2017)

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Volume 14, Issue 10, Pages 1442-1448 (October 2017) Sodium-channel blocker challenge in the familial screening of Brugada syndrome: Safety and predictors of positivity Dylan Therasse, MD, Frederic Sacher, MD, Bertrand Petit, MD, Dominique Babuty, MD, PhD, Philippe Mabo, MD, PhD, Raphael Martins, MD, PhD, Laurence Jesel, MD, Philippe Maury, MD, PhD, Jean Luc Pasquie, MD, PhD, Jacques Mansourati, MD, PhD, Jean Marc Dupuis, MD, Florence Kyndt, PharmaD, PhD, Aurélie Thollet, PharmaD, PhD, Beatrice Guyomarch, MS, Julien Barc, PhD, Jean Jacques Schott, PhD, Herve Le Marec, MD, PhD, Richard Redon, PhD, Vincent Probst, MD, PhD, Jean-Baptiste Gourraud, MD, PhD Heart Rhythm Volume 14, Issue 10, Pages 1442-1448 (October 2017) DOI: 10.1016/j.hrthm.2017.06.031 Copyright © 2017 Heart Rhythm Society Terms and Conditions

Figure 1 Example of a positive sodium-channel blocker challenge (SCBC). The test (ajmaline 1 mg/kg over 10 minutes) was performed in an asymptomatic 18-year-old woman after the identification of asymptomatic Brugada syndrome in her father. Note the S wave in leads DII and DIII on the baseline electrocardiogram (ECG) and the QRS fragmentation in precordial leads. Measurements performed in 3 consecutive beats reveal a significant increased in the PR interval (from 268 to 304 ms), the QRS interval (from 81 to 143 ms), and the QT interval (from 381 to 420 ms) during the test. All ECGs were performed with a speed of 25 mm/s and an amplitude of 10 mm/mV. No complication occurred during the test. Heart Rhythm 2017 14, 1442-1448DOI: (10.1016/j.hrthm.2017.06.031) Copyright © 2017 Heart Rhythm Society Terms and Conditions

Figure 2 Proportion of positive and complicated sodium-channel blocker challenge (SCBC) according to QRS enlargement. Percentage of positive SCBC according to QRS enlargement is represented in blue. Percentage of complicated SCBC according to QRS enlargement is represented in red. Heart Rhythm 2017 14, 1442-1448DOI: (10.1016/j.hrthm.2017.06.031) Copyright © 2017 Heart Rhythm Society Terms and Conditions