Critical Reviews in Oncology / Hematology

Slides:

Advertisements

Similar presentations

Cancer Immunoediting Integrating Immunity’s Roles in Cancer Suppression and Promotion Omer GULLULU.

Advertisements

Immune dysfunction & its consequences

Host Defense Against Tumors (Tumor Immunity)

Gastric cancer Critical Reviews in Oncology / Hematology

Cancer and the Immune System

Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review Cloé Brami, Ting Bao, Gary Deng Critical.

Novel targets in gastric and esophageal cancer

David P. Carbone, MD, PhD, David R. Gandara, MD, Scott J

Sorafenib-based combination as a first line treatment for advanced hepatocellular carcinoma: A systematic review of the literature Omar Abdel-Rahman,

Building the bridge between rhabdomyosarcoma in children, adolescents and young adults: The road ahead J. Carlijn Van Gaal, Eveline S.J.M. De Bont, Suzanne.

Incidence and clinical impact of chemotherapy induced myelotoxicity in cancer patients: An observational retrospective survey Lazzaro Repetto Critical.

Suzanne L. Topalian, Charles G. Drake, Drew M. Pardoll Cancer Cell

Genistein: Its role in metabolic diseases and cancer

Abhimanyu Ghose, Ria Kundu, Tahir Latif

Olfa Baroudi, Amel Benammar-elgaaied

Cancer and the Immune System

Critical Reviews in Oncology / Hematology

Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence Ashish Singhal, Muralidharan Jayaraman, Danny.

Precision medicine in ALK rearranged NSCLC: A rapidly evolving scenario Alfredo Addeo, Fabrizio Tabbò, Tim Robinson, Lucio Buffoni, Silvia Novello Critical.

Immunotherapy, an evolving approach for the management of triple negative breast cancer: Converting non-responders to responders Mai F. Tolba, Hany A.

Gerhard J. Molderings Critical Reviews in Oncology / Hematology

Cancer: Inappropriate Expression of Stem Cell Programs?

Challenges in the Development of Effective Peptide Vaccines for Cancer

Discussion Outline Cells of the Immune System.

Immunoengineering: How Nanotechnology Can Enhance Cancer Immunotherapy

Tumor Immunology Ali Al Khader, MD Faculty of Medicine

Msc clinical immunology

Immune Prophets of Lung Cancer: The Prognostic and Predictive Landscape of Cellular and Molecular Immune Markers Ivana Catacchio, Anna Scattone, Nicola.

Pathogen-Mediated Posttranslational Modifications: A Re-emerging Field

Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO)

Antibody-modified T cells: CARs take the front seat for hematologic malignancies by Marcela V. Maus, Stephan A. Grupp, David L. Porter, and Carl H. June.

Gut Microbiota: A Natural Adjuvant for Vaccination

Oncology Meets Immunology: The Cancer-Immunity Cycle

Some DCs Are “B”etter Immunity

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Megan E. Daly, MD, Arta M. Monjazeb, MD, PhD, Karen Kelly, MD

David P. Carbone, MD, PhD, David R. Gandara, MD, Scott J

Tumor Evolution: A Problem of Histocompatibility

Hiding in Plain Sight: How Cancer Evades the Immune System

Combined Radiotherapy and Anti–PD-L1 Antibody Synergistically Enhances Antitumor Effect in Non–Small Cell Lung Cancer Xiaomei Gong, MD, PhD, Xuefei Li,

Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side

Volume 134, Issue 5, Pages (May 2008)

Laurence Zitvogel, Guido Kroemer Cancer Cell

Miki Ando, Hiromitsu Nakauchi Experimental Hematology

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Targets for immunotherapy of liver cancer

Checkpoint blockade therapy resistance in Hodgkin's lymphoma

ER Stress in Dendritic Cells Promotes Cancer

Wilberto Nieves-Neira, J. Julie Kim, Daniela Matei

Robert J Korst, MD, Ronald G Crystal, MD

Mechanisms of immune escape in the tumor microenvironment.

Microbiome and Anticancer Immunosurveillance

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy

Tumor Promotion via Injury- and Death-Induced Inflammation

Imatinib in Dermatofibrosarcoma: Targeted Therapy or Immunotherapy?

Wenjun Ouyang, Anne O’Garra Immunity

Volume 14, Issue 4, Pages (October 2008)

T Cell Dysfunction in Cancer

Cancer Evolution during Immunotherapy

Sterile Inflammation Fuels Gastric Cancer

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance Laurence Zitvogel, Lorenzo Galluzzi, Mark J. Smyth,

Releasing the Brakes on Cancer Immunotherapy

Vaccines for Lung Cancer

All Roads Lead to the Ribosome

Some DCs Are “B”etter Immunity

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

(A) Lymph node priming phase: recognition of major histocompatibility complex (MHC) by T-cell receptor (TCR), coactivating CD 28/B7 pathway activation.

Cytokine Gene Therapy for Malignant Pleural Mesothelioma

Immunological effects of anticancer therapy.

Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

Presentation transcript:

Critical Reviews in Oncology / Hematology Radiotherapy in the age of cancer immunology: Current concepts and future developments Mauro Loi, Isacco Desideri, Daniela Greto, Monica Mangoni, Mariangela Sottili, Icro Meattini, Carlotta Becherini, Francesca Terziani, Camilla Delli Paoli, Emanuela Olmetto, Pierluigi Bonomo, Lorenzo Livi Critical Reviews in Oncology / Hematology Volume 112, Pages 1-10 (April 2017) DOI: 10.1016/j.critrevonc.2017.02.002 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Cancer Immunoediting theory. (A) ELIMINATION: aberrant antigene-expressing cancer cells are detected and attacked by the host immune system (B) EQUILIBRIUM: emergence of clones resistant to immune rejection (C) ESCAPE: tumor cells thwart immune response due to poor antigene expression and recruitment of immunosuppressive cells. Critical Reviews in Oncology / Hematology 2017 112, 1-10DOI: (10.1016/j.critrevonc.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Effects of radiation on cancer immune environment. (A) Immunogenic Cell Death: release of chemical byproducts of radiation-induced cell death thrive anti-tumor immune response through stimulation of antigene processing and lymphocyte priming (B) Vascular modifications allows recruitment of immune infiltration from the bloodstream (C) Exposure to radiation induce expression of major histocompatibility complex (MHC) I on cancer cells surface, that facilitate immune recognition. Critical Reviews in Oncology / Hematology 2017 112, 1-10DOI: (10.1016/j.critrevonc.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Strategies to obtain immunity-enhanced radiotherapy (A) Antigene-based cancer vaccines (B) Targeting intracellular signalization pathways involved in immune response modulation (C) Targeting resident intratumoral population of immunosuppressive cells (M2 macrophages, T-regulator lymphocytes, Myeloid-derived stem cells). (D) Immune check point inhibition (E) Altered fractionations and heavy particles therapy. Critical Reviews in Oncology / Hematology 2017 112, 1-10DOI: (10.1016/j.critrevonc.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions