Volume 371, Issue 9618, Pages (March 2008)

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Volume 371, Issue 9618, Pages 1085-1097 (March 2008) Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial Prof René S Kahn, MD, Prof W Wolfgang Fleischhacker, MD, Han Boter, PhD, Prof Michael Davidson, MD, Yvonne Vergouwe, PhD, Ireneus PM Keet, MD, Prof Mihai D Gheorghe, MD, Prof Janusz K Rybakowski, MD, Prof Silvana Galderisi, MD, Prof Jan Libiger, MD, Prof Martina Hummer, MD, Prof Sonia Dollfus, MD, Prof Juan J López-Ibor, MD, Luchezar G Hranov, MD, Prof Wolfgang Gaebel, MD, Prof Joseph Peuskens, MD, Prof Nils Lindefors, MD, Prof Anita Riecher-Rössler, MD, Prof Diederick E Grobbee, MD The Lancet Volume 371, Issue 9618, Pages 1085-1097 (March 2008) DOI: 10.1016/S0140-6736(08)60486-9 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2008 371, 1085-1097DOI: (10.1016/S0140-6736(08)60486-9) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Time to treatment discontinuation because of any cause (A), insufficient efficacy (B), side-effects (C), and non-adherence (D) The Lancet 2008 371, 1085-1097DOI: (10.1016/S0140-6736(08)60486-9) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 3 PANSS total score (A), CGI severity score (B), and GAF score (C) during 12 months of follow-up PANSS=positive and negative syndrome scale. CGI=clinical global impression. GAF=global assessment of functioning. The lowest curve for GAF scores consists of the haloperidol and quetiapine curves, which are almost identical. The Lancet 2008 371, 1085-1097DOI: (10.1016/S0140-6736(08)60486-9) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 4 Time to treatment discontinuation for any cause in patients assigned to haloperidol at sites at which the coordinator thought that haloperidol was the worst option, versus sites at which the coordinator believed that it was not The Lancet 2008 371, 1085-1097DOI: (10.1016/S0140-6736(08)60486-9) Copyright © 2008 Elsevier Ltd Terms and Conditions