Body Composition, Cardiorespiratory Fitness, and Low-Grade Inflammation in Middle- Aged Men and Women  Benoit J. Arsenault, MSc, Amélie Cartier, MSc, Mélanie Côté, MSc, Isabelle Lemieux, PhD, Angelo Tremblay, PhD, Claude Bouchard, PhD, Louis Pérusse, PhD, Jean-Pierre Després, PhD  American Journal of Cardiology  Volume 104, Issue 2, Pages 240-246 (July 2009) DOI: 10.1016/j.amjcard.2009.03.027 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Plasma levels of CRP, adiponectin, interleukin-6, and tumor necrosis factor-α in (A) men and (B) women classified by visceral AT accumulation (<130 or ≥130 cm2 in men and <100 or ≥100 cm2 in women) and CRF levels (<1.7 or ≥10.7 kpm/kg in men and <6.9 or ≥6.9 kpm/kg in women). 1,2,3Significantly different from corresponding subgroup (p <0.05, on log-transformed values). American Journal of Cardiology 2009 104, 240-246DOI: (10.1016/j.amjcard.2009.03.027) Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 2 Proportion of subjects with an increased inflammation score in participants classified by (A) BMI (<25 or ≥25 kg/m2) and CRF (<10.7 or ≥10.7 kpm/kg in men and <6.9 or ≥6.9 kpm/kg in women) or (B) visceral AT accumulation (<130 or ≥130 cm2 in men and <100 or ≥100 cm2 in women) and CRF. The inflammation score was defined as the sum of the number of inflammatory markers >50th percentile (CRP, tumor necrosis factor-α, and interleukin-6) or <50th percentile for adiponectin. 1,2,3Significantly different from corresponding subgroup (p <0.05). American Journal of Cardiology 2009 104, 240-246DOI: (10.1016/j.amjcard.2009.03.027) Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 3 Mean inflammation score in participants classified by plasma glucose area under the curve (AUC) measured during the oral glucose tolerance test and by visceral AT accumulation (A) or CRF levels (B) and by insulin AUC measured during the oral glucose tolerance test and by visceral AT accumulation (C) or CRF levels (D). The inflammation score was defined as the sum of the number of inflammatory markers >50th percentile (CRP, tumor necrosis factor-α, and interleukin-6) or <50th percentile for adiponectin. In men, cut-off values of 1.16 mmol/L/min × 10−3 and of 56.5 pmol/L/min × 10−3, respectively, for glucose and insulin areas under the curve during the oral glucose tolerance test were used to classify participants with low or high values corresponding to median values observed in the sample of men. In women, these respective cut-off values corresponded to 1.10 mmol/L/min × 10−3 and 59.1 pmol/L/min × 10−3. 1,2,3Significantly different from corresponding subgroups (p <0.05). American Journal of Cardiology 2009 104, 240-246DOI: (10.1016/j.amjcard.2009.03.027) Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 4 Relation between BMI and visceral AT accumulation in men (straight line) and women (dashed line). American Journal of Cardiology 2009 104, 240-246DOI: (10.1016/j.amjcard.2009.03.027) Copyright © 2009 Elsevier Inc. Terms and Conditions