Dutch Melanoma Treatment Registry: Quality assurance in the care of patients with metastatic melanoma in the Netherlands Anouk Jochems, Maartje G. Schouwenburg,

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Dutch Melanoma Treatment Registry: Quality assurance in the care of patients with metastatic melanoma in the Netherlands Anouk Jochems, Maartje G. Schouwenburg, Brenda Leeneman, Margreet G. Franken, Alfons J.M. van den Eertwegh, John B.A.G. Haanen, Hans Gelderblom, Carin A. Uyl-de Groot, Maureen J.B. Aarts, Franchette W.P.J. van den Berkmortel, Willeke A.M. Blokx, Mathilde C. Cardous-Ubbink, Gerard Groenewegen, Jan Willem B. de Groot, Geke A.P. Hospers, Ellen Kapiteijn, Rutger H. Koornstra, Wim H. Kruit, Marieke W. Louwman, Djura Piersma, Rozemarijn S. van Rijn, Albert J. ten Tije, Gerard Vreugdenhil, Michel W.J.M. Wouters, Jacobus J.M. van der Hoeven European Journal of Cancer Volume 72, Pages 156-165 (February 2017) DOI: 10.1016/j.ejca.2016.11.021 Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 1 Organisational structure of the Dutch Melanoma Treatment Registry (DMTR). NVMO, Dutch Society of Medical Oncologists; WIN-O, the Working Group on Immunotherapy and Oncology; Stichting Melanoom, patient association; iMTA, Institute for Medical Technology Assessment; ZonMW, Netherlands Organisation for Health Research and Development; ZiNL, National Health Care Institute; DICA, Dutch Institute for Clinical Auditing and IKNL, the Netherlands Comprehensive Cancer Organisation. European Journal of Cancer 2017 72, 156-165DOI: (10.1016/j.ejca.2016.11.021) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 2 Treatment patterns of all systemically treated patients with metastatic melanoma, presented by line of systemic therapy and year of registration. European Journal of Cancer 2017 72, 156-165DOI: (10.1016/j.ejca.2016.11.021) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 3 Variation between melanoma centres in the percentage of patients with grade III–IV AEs caused by a BRAF inhibitor (A) and/or ipilimumab (B). The dotted line presents the average percentage of patients who experienced grade III–IV AEs. AE = adverse event. European Journal of Cancer 2017 72, 156-165DOI: (10.1016/j.ejca.2016.11.021) Copyright © 2016 Elsevier Ltd Terms and Conditions