Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: A manually actuated clamp employed as a resistance mechanism by Legendre et al. [6] (left). An example of a Hass (New York, NY) proportional pinch valve as an automated solution to resistance actuation by Timms et al. [5] (right).

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: 3.

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: Resistor as installed in the mock circulatory loop. The elements of the design are as follows: (1) vertical optical rail, (2) linear actuator lead screw, (3) stepper motor, (4) resistor motor frame, (5) rotation constraint bar, (6) piston, (7) flow inlet, (8) 1 of 4 mounting holes for optical rail attachment, (9) flow outlet, (10) potentiometer, and (11) connector with cable leading to driver board (11).

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: LabVIEW interface used to control the resistor and collect data. The slider allows for a position to be selected and the radix below it enables a particular set point to be entered. The read back is the intermittently updated position read back from the position controller. The button at the bottom communicates the new set point to the controller, initiating the movement of the resistor. This panel can be inserted into other LabVIEW interfaces when constructing control panels for mock circulatory loops, where this device would be a subsystem.

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: Modified mock circulatory loop used in this analysis; the black arrow counter clockwise from pump indicates flow direction. The order of the pump, compliance chamber, resistor, and venous reservoir is consistent with a mock circulatory loop design. The purpose of pressure sensors downstream of the compliance chamber and resistor is to acquire differential pressure across the resistor. The flowmeter has been repositioned downstream of the resistor for better acuity in flow rate measurement for this segment of the loop. The upstream and downstream throttling valves provide fluid flow regulation and backpressure control, respectively [10].

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: SIMULINK™ model of the experimental system utilizing simscape blocks to model the physical components of the mock circulatory loop. The simulated flow is from left to right, with components similar to those described in the experimental setup and in Fig. 2. The experimental flow sensor data is permuted as a flow source in the computational model; the model needs a volume source. The downstream pressure sensor experimental data is represented as a pressure source in the model, since there needs to be an exit condition for the simulated flow.

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: The top graph depicts the tuning dataset with the result of the model using the tuned values to that of the experimental dataset for the upstream resistor. The flow rate graph (middle graph) indicates that an approximately constant flow was maintained through the resistor movement (bottom graph).

Date of download: 10/9/2017 Copyright © ASME. All rights reserved. From: Implementation of an Automated Peripheral Resistance Device in a Mock Circulatory Loop With Characterization of Performance Values Using Simulink Simscape and Parameter Estimation J. Med. Devices. 2012;6(4):045001-045001-7. doi:10.1115/1.4007458 Figure Legend: Performance of the tuned SIMULINK™ model using input data with different conditions to that of the tuning data. The model simulation at the lower flow rate showed signs of sensitivity to the fluctuations in flow, which was also seen in the tuning data. The similarity of the simulation to the experimental data provides verification that the parameter estimation was a success.