APPLICATIONS OF CYTOTOXICITY

Index What is Cytotoxicity ( introduction) Applications :- Testing Pharmaceuticals Anticancer Drug Screening Predictive Drug Testing For Tumors

What is Cytotoxicity ? Cytotoxicity is the degree to which an agent has specific destructive action on certain cells The possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells.

Application of Cytotoxicity TESTING PHARMACEUTICALS In vitro testing of drugs on animals is expensive . This animal drug testing is ethically non-acceptable. The animals testing of drugs is difficult to introduce as complexity of wide range of effects seen in vivo. But with Cytotoxicity assay, researchers can look for Cytotoxic compounds that targets rapidly dividing cancer cells.

ANTICANCER DRUG SCREENING In this the drug screening and dosage is checked In this cutting down on manipulations the MTT(methyl tetrazolium) incubation step and the point determined by measuring the amount of total protein with sulforhodamine B may be omitted. This method is easier and quicker then the MTT assay.

PREDICTIVE DRUG TESTING FOR TUMORS In this the testing of predictive drug designs are done which can localize the tumor.

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