Volume 123, Issue 3, Pages 664-666 (March 2016) Nonleaking Cystoid Macular Edema as a Presentation of Hydroxychloroquine Retinal Toxicity  Vishal S. Parikh, MD, Yasha S. Modi, MD, Adrian Au, BA, Justis P. Ehlers, MD, Sunil K. Srivastava, MD, Andrew P. Schachat, MD, Rishi P. Singh, MD  Ophthalmology  Volume 123, Issue 3, Pages 664-666 (March 2016) DOI: 10.1016/j.ophtha.2015.09.011 Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 1 A-D, Case 1. A, Bilateral retinal pigment epithelium (RPE) atrophy in a bull's eye pattern. B, Fluorescein angiogram (FA) shows late central hypofluorescence with a rim of nonexpanding paracentral hyperfluorescence. C, Spectral-domain optical coherence tomography (SD OCT) shows loss of the ellipsoid zone and outer retinal layers along with cystoid macular edema (CME). D, Fundus autofluorescence shows parafoveal hypoautoflourescence and hyperautofluorescence indicative of RPE loss and dysfunction. E-H, Case 2. E, Edema with associated parafoveal RPE changes. F, Central hypofluorescence on FA without late leakage. G, Parafoveal loss of outer retinal layers along with CME on SD OCT. H, Fundus autofluorescence demonstrates parafoveal hypoautofluorescence and hyperautofluorescence indicative of RPE loss and dysfunction. Ophthalmology 2016 123, 664-666DOI: (10.1016/j.ophtha.2015.09.011) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions