EPIRETINAL MEMBRANES IN PATIENTS WITH UVEITIS: MORPHOLOGICAL AND FUNCTIONAL ANALYSIS WITH SPECTRL-DOMAIN OPTICAL L. Iannetti, P. Tortorella, R. Spena,

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EPIRETINAL MEMBRANES IN PATIENTS WITH UVEITIS: MORPHOLOGICAL AND FUNCTIONAL ANALYSIS WITH SPECTRL-DOMAIN OPTICAL L. Iannetti, P. Tortorella, R. Spena, R. Zito, A. Sapia, E. D’Ambrosio “Sapienza” University of Rome Department of Ophthalmology Ocular Immunovirology Service Hamburg 26-29 September 2013 13th Euretina Congress

INTRODUCTION Macular epiretinal membrane (ERM) is a pathology caused by a fibrocellular proliferation on the inner limiting membrane followed by cellular contraction Contraction causes macular dysfunction metamorphopsia visual reduction central unilateral diplopia

PURPOSE To correlate the uveitic ERM features observed by Spectral-Domain Optical Coherence Tomography (SD-OCT) with visual acuity (BCVA)

Morphological and clinical features METHODS METHODS: 41 eyes of 32 patients Retrospective study SD- OCT BCVA ERM THICKNESS First time Diagnosis Second time Final visit Morphological and clinical features Fig. 1 a. focal pattern of ERM attachment , b. broad pattern of ERM attachment, c.foveal involvement of ERM, d. no foveal involvement of ERM. Fig. 2 loss of foveal concavity, b. precence of foveal concavity, c. presence of cystoid macular edema, d. absence of cystoid macular edema.

BCVA BCVA CHANGE RESULTS RESULTS positively correlated with: male sex (p<0.01) and focal pattern of ERM attachment (p<0.05) BCVA negatively correlated with: with IS/OS photoreceptor junction distruption (p<0.05) positively correlation with: the age of ERM onset (p<0.1) BCVA CHANGE negatively correlation with: IS/OS photoreceptor distruption at the ERM diagnosis (p<0.05) increase of central subfield thickness (p<0.1) Fig. 3 a. disruption of IS/OS photoreceptor junction, b. integrity of IS/OS photoreceptor junction, c. disruption of ELM, d. integrity of ELM.

CONCLUSIONS RESULTS During the follow-up ERM thickness correlated with: male sex (p <0.05) posterior uveitis (p<0.05) uveitis duration (p<0.05) broad attachment pattern (p<0.1) Final ERM thickness correlated with: duration of uveitis (p<0.01) duration of ERM (p<0.001) FINANCIAL DISCLOSURE: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.