Non ischemic cardiomyopathy and low burden of scar as revealed by an ECG-score: No need for a defibrillator in special patients after cardiac resynchronisation?

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Presentation transcript:

Non ischemic cardiomyopathy and low burden of scar as revealed by an ECG-score: No need for a defibrillator in special patients after cardiac resynchronisation? Grett M, Trappe HJ Department of Cardiology and Angiology University of Bochum, Germany

the modified Selvester-ECG-score (MSES) changes in QRS-complex correlate with the extend of myocardial scar estimation of scar by Selvester-Score shows high correlation with autopsy-measured myocardial infarct size Selvester-Score was modified to deliver information in patients with conduction defect and non ischemic cardiomyopathy

the modified Selvester-ECG-score (MSES) for detailed information on the history of the MSES: A detailed guide for quantification of myocardial scar with the Selvester QRS score in the presence of electrocardiogram confounders. Loring Z, Chelliah S, Selvester RH, Wagner G, Strauss DG. J Electrocardiol. 2011 Sep-Oct;44(5):544-54

Example Loring Z, Chelliah S, Selvester RH, Wagner G, Strauss DG. J Electrocardiol. 2011 Sep-Oct;44(5):544-54

Example Loring Z, Chelliah S, Selvester RH, Wagner G, Strauss DG. J Electrocardiol. 2011 Sep Oct;44(5):544-54

MSES as a prognostic tool higher MSES correlates with greater risk for adequate ICD-therapies Strauss, D.G., Poole, J.E., Wagner, G.S., Selvester, R.H., Miller, J.M., Anderson, J., Johnson, G., McNulty, S.E., Mark, D.B., Lee, K.L., Bardy, G.H., Wu, K.C. (2011). An ECG index of myocardial scar enhances prediction of defibrillator shocks: an analysis of the Sudden Cardiac Death in Heart Failure Trial. Heart Rhythm 8 (1), 38-45 lower MSES predicts reverse remodeling by CRT Sweeney, M.O., van Bommel, R.J., Schalij, M.J., Borleffs, C.J., Hellkamp, A.S., Bax, J.J. (2010) Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapy. Circulation 121 (5), 626-634

MSES as a prognostic tool higher MSES correlates with greater risk for adequate ICD-therapies lower MSES predicts greater reverse remodeling by CRT combining these findings with being convinced that reverse remodeling reduces the risk for sustained VT and the belief in a classic model of scar as a substrate and ischemia as a trigger for VT lead to our study

No need for a defibrillator in special patients after cardiac resynchronisation? Retrospective subgroup analysis 74 pts who underwent CRT-D implantation complete follow up of device interrogations for 3 years at our department Exclusion: secondary prophylactic indication for ICD, upgrade from existing devices, long-QT, channelopathies

No need for a defibrillator in special patients after cardiac resynchronisation? Median LVEF 20% (range 10,0%-29,0%) median ECG-score 4 (0-12) 85% male mean age 65,7 years ischemic (ICM) 33 pts, non-ischemic (NICM) 41 25/74 suffered adequate ICD-therapy in 3 year period

No need for a defibrillator in special patients after cardiac resynchronisation?