NAMED REACTIONS

A reaction which is based on scientist name or product name is called as NAMED REACTION. A reagent which is based on scientist name or product name is called as NAMED REAGENT.

FAMILIAR NAMED REACTIONS: SOME OF THE IMPORTANT NAMED REACTIONS 1. BECKMANN’S REARRANGEMENT 2.FRIES REARRANGEMENT 3. SCHIMDT’S REARRANGEMENT 4.OPPENAUIRE’S OXIDATION 5.CLEMMENSEN’S REDUCTION 6.MANNICH REACTION 7.PHILLIPS REACTION

BECKMANN’S REARRANGEMENT Def: A rearrangement reaction in which conversion of keto oxine into N-substituted amide in presence of SULPHURIC ACID is called as beckmann’s rearrangement. CATALYST: Conc.H2SO4 ,PCl 5 , PCl 3

GENERAL MECHANISM

APPLICATIONS: 1. Determines the configuration of keto- oximes 2 APPLICATIONS: 1. Determines the configuration of keto- oximes 2.Synthesis of caprolactom from cyclohexanoxime 3.Synthesis of Isoquinoline from Cinnamaldoxime

FRIES REARRANGEMENT Def: A rearrangement reaction in which Aromatic Ester undergo reaction converts to Aromatic ketone in presence of ALLUMINIUM CHLORIDE. CATALYST: Anhydrous alluminium chloride

GENERAL REACTION

Applications: 1.Synthesis of Adrenaline 2.Synthesis of catachol esters

SCHIMDT’s REARRANGEMENT Def: when a carboxylic acid undergo reaction with Hydraloicacid in the presence of conc sulphuricacid gives corresponding Amine is called schimdth rearrangement. CATALYST: Sulphuricacid

GENERAL REACTION

Applications: 1.preparation of Amines 2.synthesis of L-amino acid

OPPENAUER’S OXIDATION Def: when a secondary alcohol undergo reflexation with a Ketone in the presence of Alluminium tertiory butoxide on oxidation results formation of ketone along with secondary alcohol. Catalyst: Aluminium tertiory butaoxide.

GENERAL MECHANISM

Applications: 1. Synthesis of 6 methyl 3,5,7-octatriene-2-one 2 Applications: 1.Synthesis of 6 methyl 3,5,7-octatriene-2-one 2.Synthesis of L- decanone 3.Synthesis of cholesterol

CLEMMENSEN’S REDUCTION Def: when a carbonyl compounds undergo reduction in the presence of zinc amalgum in conc.HCl gives corresponding hydrocarbons as active methylene group compound. Catalyst: Conc.zn-Hg/Hcl

GENERAL MECHANISM

Applications: 1. Reduction of aromatic & aliphatic carbonyl compounds 2.Reduction of keto acids 3.Reduction of phenolic carbonyl compounds

MANNICH REACTION Def: condensation reaction which involves the ketone reaction with formaldehyde and primary or secondary amine to give mannich base is called mannich reaction. Catalyst: No catalyst

GENERAL REACTION

APPLICATIONS: 1. synthesis of Cocaine 2.synthesis of Tutocaine

PHILLIPS REACTION Def: when orthophynylene diamine undergo reaction with carboxylic acid in the presence of base it undergo cyclisation and form benzimidazole as product. Catalyst: 10% of NaOH

GENERAL MECHANISM:

Applications: 1.Philips reaction is generally used for synthesis of heterocyclic compounds 2.Ortho phenylene diamine undero reaction which acetic acid to aceto benzimidazole

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